Production of heterogenous bone radiopacity phantom using 3D printing.

IF 2.4 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Seyide Tugce Gokdeniz, Arda Buyuksungur, Mehmet Eray Kolsuz
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Abstract

The aim is to obtain a heterogenous bone radiopacity phantom with adjustable radiopacity in different regions. The heterogenous 3D printed phantom can be used as bone equivalent in medical education, surgical planning, diagnostic radiology, and radiotherapy. This study utilized a hybrid approach, combining both direct and indirect methods, to create phantoms with realistic bone-equivalent radiodensity. Hollow, cube-shaped test blocks were produced using an SLA 3D printer with a photoreactive resin. The attenuation coefficients of the test blocks were evaluated using Dataviewer software by comparing materials such as calcium sulfate dihydrate, barium sulfate, and hydroxyapatite. The photoreactive resin was modified with hydroxyapatite to increase its radiodensity. A hollow jaw phantom model was then designed and printed using the hydroxyapatite-doped resin. The powder hydroxyapatite was added to the cavities of the printed phantom model. The average attenuation coefficient of barium sulfate was 208 ± 1.90 mm- 1, calcium sulfate dihydrate was 187 ± 1.98 mm- 1, hydroxyapatite was 128 ± 2.35 mm- 1, and bone values, which were considered as reference values in the research, was 125 ± 14 mm- 1. The observed difference between the hydroxyapatite added bone model and real bone was not statistically significant (Z:-0.175, p:0.860). The produced mandibular bone phantom has realistic attenuation coefficient values and heterogeneity in terms of radiological features. This study shows that the use of two different methods, which include hydroxyapatite material added into the photoreactive resin during the 3D printing process and the addition of hydroxyapatite as a powder to the gaps in the bone model obtained after printing, yields successful results in the production of bone-equivalent phantoms.

利用3D打印技术制作异质骨透影。
目的是获得不同区域可调节的异质骨透影。异质3D打印的假体可以在医学教育、手术计划、放射诊断和放射治疗中用作骨等同物。本研究采用了一种混合方法,结合直接和间接的方法,创造了具有真实骨等效放射密度的模型。使用带有光反应性树脂的SLA 3D打印机制作中空的立方体测试块。通过比较二水合硫酸钙、硫酸钡和羟基磷灰石等材料,使用Dataviewer软件评估测试块的衰减系数。用羟基磷灰石对光反应树脂进行改性以提高其放射密度。然后利用羟基磷灰石掺杂树脂设计并打印了空心颚体模型。将粉末羟基磷灰石添加到打印的幻影模型的空腔中。硫酸钡的平均衰减系数为208±1.90 mm- 1,二水合硫酸钙的平均衰减系数为187±1.98 mm- 1,羟基磷灰石的平均衰减系数为128±2.35 mm- 1,骨值为125±14 mm- 1,作为研究的参考值。羟基磷灰石添加骨模型与真骨的观察差异无统计学意义(Z:-0.175, p:0.860)。所产生的下颌骨影具有真实的衰减系数值和放射学特征的异质性。本研究表明,使用两种不同的方法,包括在3D打印过程中将羟基磷灰石材料添加到光反应树脂中,以及在打印后获得的骨模型间隙中添加羟基磷灰石作为粉末,可以成功地生产出骨等效模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.40
自引率
4.50%
发文量
110
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