Value of Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratios in Differentiating Idiopathic Orbital Inflammation From Orbital Infectious Disease.

IF 1.2 4区 医学 Q3 OPHTHALMOLOGY
Robert J Thomson, Carisa E Bohnak, Edward J Wladis
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引用次数: 0

Abstract

Purpose: Monocyte-lymphocyte ratio (MLR) and platelet-lymphocyte ratio (PLR) are emerging biomarkers; they have not been widely utilized in orbital disease. This study investigated the role of these ratios in distinguishing orbital inflammation from infection.

Methods: A retrospective review of medical records was conducted to identify adult patients who presented acutely to a single emergency department at an academic medical center and were diagnosed with serologically and biopsy-proven idiopathic orbital inflammation (IOI, n = 9), orbital cellulitis (OC, n = 14), or necrotizing fasciitis (NF, n = 12). MLR and PLR were calculated from the first blood draw on presentation to the emergency department. Statistical analysis was performed via the Mann-Whitney test with a dedicated computerized software package (GraphPad Prism, La Jolla, CA) with p values <0.05 considered statistically significant.

Results: Mean PLRs were 194.90 (SD = 118.01), 304.21 (SD = 341.39), and 203.38 (SD = 196.32) for IOI, NF, and OC, respectively. Mean MLRs were 0.40 (SD = 0.24), 1.74 (SD = 2.41), and 0.75 (SD = 0.40) for IOI, NF, and OC, respectively. MLR was significantly lower in the IOI group compared to the NF group ( p = 0.018) and OC group ( p = 0.020). Differences in MLR between OC and NF groups were not statistically significant ( p = 0.43).

Conclusion: While MLR showed no significant difference between different infectious etiologies, it was significantly higher in infectious processes than in IOI, distinguishing inflammation from infection. MLR could be a valuable addition to the diagnostic toolkit for triaging patients in the emergency department and initiating prompt, focused therapy.

血小板与淋巴细胞及单核细胞与淋巴细胞比值在鉴别特发性眼窝炎症与眼窝感染性疾病中的价值。
目的:单核细胞-淋巴细胞比率(MLR)和血小板-淋巴细胞比率(PLR)是新兴的生物标志物;它们在眼眶疾病中尚未得到广泛应用。本研究探讨了这些比率在区分眼眶炎症和感染中的作用。方法:回顾性分析在某学术医疗中心急诊就诊并经血清学和活检证实为特发性眼窝炎(IOI, n = 9)、眼窝蜂窝织炎(OC, n = 14)或坏死性筋膜炎(NF, n = 12)的成年患者的医疗记录。MLR和PLR从首次抽血到急诊科开始计算。统计学分析采用专用计算机软件包(GraphPad Prism, La Jolla, CA)进行Mann-Whitney检验,p值为p值。结果:IOI、NF和OC的平均plr分别为194.90 (SD = 118.01)、304.21 (SD = 341.39)和203.38 (SD = 196.32)。IOI、NF和OC的平均MLRs分别为0.40 (SD = 0.24)、1.74 (SD = 2.41)和0.75 (SD = 0.40)。IOI组MLR明显低于NF组(p = 0.018)和OC组(p = 0.020)。两组间MLR差异无统计学意义(p = 0.43)。结论:虽然MLR在不同感染病因间无显著差异,但在感染过程中MLR明显高于IOI,区分了炎症与感染。MLR可能是诊断工具包的一个有价值的补充,用于在急诊科对患者进行分类,并开始及时、集中的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.50
自引率
10.00%
发文量
322
审稿时长
3-8 weeks
期刊介绍: Ophthalmic Plastic and Reconstructive Surgery features original articles and reviews on topics such as ptosis, eyelid reconstruction, orbital diagnosis and surgery, lacrimal problems, and eyelid malposition. Update reports on diagnostic techniques, surgical equipment and instrumentation, and medical therapies are included, as well as detailed analyses of recent research findings and their clinical applications.
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