Automated method of bronchus and artery dimension measurement in an adult bronchiectasis population.

IF 4.3 3区医学 Q1 RESPIRATORY SYSTEM

ERJ Open Research Pub Date : 2024-12-09 eCollection Date: 2024-11-01 DOI:10.1183/23120541.00231-2024

Angelina L P Pieters, Qianting Lv, Jennifer J Meerburg, Tjeerd van der Veer, Eleni-Rosalina Andrinopoulou, Pierluigi Ciet, James D Chalmers, Michael R Loebinger, Charles S Haworth, J Stuart Elborn, Harm A W M Tiddens

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引用次数: 0

Abstract

Aim: Bronchiectasis (BE) is a disease defined by irreversible dilatation of the airway. Computed tomography (CT) plays an important role in the detection and quantification of BE. The aim of this study was three-fold: 1) to assess bronchus-artery (BA) dimensions using fully automated software in a cohort of BE disease patients; 2) to compare BA dimensions with semi-quantitative BEST-CT (Bronchiectasis Scoring Technique for CT) scores for BE and bronchial wall thickening; and 3) to explore the structure-function relationship between BA-method lumen dimensions and spirometry outcomes.

Methods: Baseline CTs of BE patients who participated in a clinical trial were collected retrospectively. CTs were analysed manually with the BEST-CT scoring system and automatically using LungQ (v.2.1.0.1, Thirona, The Netherlands), which measures the following BA dimensions: diameters of bronchial outer wall (B_out), bronchial inner wall (B_in) and artery (A), and bronchial wall thickness (B_wt) and computes BA ratios (B_out/A and B_in/A) to assess bronchial widening. To assess bronchial wall thickness, we used the B_wt/A ratio and the ratio between the bronchus wall area (B_wa) and the area defined by the outer airway (B_oa) (B_wa/B_oa).

Results: In total, 65 patients and 16 900 BA pairs were analysed by the automated BA method. The median (range) percentage of BA pairs defined as widened was 69 (55-84)% per CT using a cut-off value of 1.5 for B_out/A, and 53 (42-65)% of bronchial wall were thickened using a cut-off value of 0.14 for B_wt/A. BA dimensions were correlated with comparable outcomes for the BEST-CT scoring method with a correlation coefficient varying between 0.21 to 0.51. The major CT BA determinants of airflow obstruction were bronchial wall thickness (p=0.001) and a narrower bronchial inner diameter (p=0.003).

Conclusion: The automated BA method, which is an accurate and sensitive tool, demonstrates a stronger correlation between visual and automated assessment and lung function when using a higher cut-off value to define bronchiectasis.

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在成人支气管扩张人群中自动测量支气管和动脉尺寸的方法。

目的：支气管扩张症（BE）是一种由气道不可逆扩张引起的疾病。计算机断层扫描（CT）在BE的检测和量化中起着重要的作用。本研究的目的有三个方面：1)在BE疾病患者队列中使用全自动软件评估支气管动脉（BA）尺寸；2)比较BA维度与半定量BEST-CT（支气管扩张评分技术）评分对BE和支气管壁增厚的影响；3)探讨ba法管腔尺寸与肺活量测定结果之间的结构-功能关系。方法：回顾性收集参加临床试验的BE患者的基线ct。ct采用BEST-CT评分系统手工分析，自动使用LungQ (v.2.1.0.1, Thirona, the Netherlands)，测量以下BA尺寸：支气管外壁（Bout）、支气管内壁（Bin）和动脉(A)的直径，以及支气管壁厚度（Bwt），并计算BA比率（Bout/A和Bin/A）来评估支气管扩张。为了评估支气管壁厚度，我们使用了Bwt/A比值和支气管壁面积（Bwa）与外气道（Boa）定义的面积（Bwa/Boa）之比。结果：采用自动BA法共分析65例患者和16900对BA。每台CT定义为增宽的BA对的中位数（范围）百分比为69 (55-84)%，Bwt/ a的临界值为1.5,53(42-65)%的支气管壁增厚，Bwt/ a的临界值为0.14。BA维度与BEST-CT评分方法的可比结果相关，相关系数在0.21至0.51之间。气流阻塞的主要CT BA决定因素是支气管壁厚度（p=0.001）和支气管内径变窄（p=0.003）。结论：自动BA法是一种准确灵敏的工具，当使用更高的临界值来定义支气管扩张时，视觉和自动评估与肺功能之间的相关性更强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ERJ Open Research Medicine-Pulmonary and Respiratory Medicine

CiteScore

6.20

自引率

4.30%

发文量

273

审稿时长

8 weeks

期刊介绍： ERJ Open Research is a fully open access original research journal, published online by the European Respiratory Society. The journal aims to publish high-quality work in all fields of respiratory science and medicine, covering basic science, clinical translational science and clinical medicine. The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.