[3 + 2] cycloaddition between cyclic diaryl λ3-bromanes and nitrones towards the formation of dihydrobenzisoxazoles and an evaluation of regioisomeric bioactivity †

IF 4.6 1区 化学 Q1 CHEMISTRY, ORGANIC
Jing-Yi Fan, Ming-Chuan Wang, Jian-Feng Zhou, Tong-Qi Gan, Wan-Xuan Zhang, Lin Wei and Bin-Jie Li
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引用次数: 0

Abstract

Here, an example of an efficient construction of important dihydrobenzisoxazole cores from cycloaddition reactions between cyclic diaryl λ3-bromanes as the aryne precursors and nitrones is reported. Many dihydrobenzisoxazole-containing compounds were synthesized under transition-metal-free conditions, and this approach was found to feature a broad substrate scope, good functional group compatibility and reasonable regioselectivities. Preliminary bioactivity evaluations demonstrated that multiple examples of these dihydrobenzisoxazoles showed potential activities against porcine reproductive and respiratory syndrome virus (PRRSV).

Abstract Image

[3+2]环二芳基- 3-溴与硝基之间的环加成反应生成二氢苯并异恶唑及其区域异构体生物活性评价
本文报道了以环二芳基λ3-溴为芳香前体与硝基之间的环加成反应高效构建重要的二氢苯并恶唑核的例子。在无过渡金属的条件下合成了许多含二氢苯并异恶唑类化合物,该方法具有底物范围广、官能团相容性好、区域选择性合理等特点。初步的生物活性评价表明,这些二氢苯并异恶唑具有抗猪繁殖与呼吸综合征病毒(PRRSV)的潜在活性。
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来源期刊
Organic Chemistry Frontiers
Organic Chemistry Frontiers CHEMISTRY, ORGANIC-
CiteScore
7.90
自引率
11.10%
发文量
686
审稿时长
1 months
期刊介绍: Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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