Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage.

IF 2.6 1区医学

Journal of Investigative Medicine Pub Date : 2024-12-08 DOI:10.1136/svn-2024-003477

Qiong Yang, Xiangzhu Zeng, Lu Tang, Xiaolu Liu, Kailin Xia, Feng Gao, Xu Huang, Nan Li, Dongsheng Fan

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Abstract

Background and objective: We investigated the association of APOE alleles with CT-based cerebral amyloid angiopathy (CAA) markers including subarachnoid extension (SAE) and finger-like projection (FLP).

Methods: We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from a multicentre cohort in China. First, the association of APOE with ICH location (lobar vs non-lobar) was evaluated. Next, the relationships of APOE with SAE, FLP, and the coexistence of the two (SAE+FLP) were evaluated.

Results: 533 patients with supratentorial ICH were enrolled. Among them were 138 patients with lobar ICH and 395 with non-lobar ICH. Compared with the non-lobar group, APOE ε4 (OR 1.894, 95% CI 1.138 to 3.154, p=0.014) and ε2/ε4 (OR 6.098, 95% CI 1.414 to 26.293, p=0.015) were associated with lobar ICH. With regard to CAA markers, APOE ε2 was associated with SAE (OR 2.109, 95% CI 1.167 to 3.810, p=0.013), ε4 was associated with FLP and SAE+FLP (OR 3.026, 95% CI 1.353 to 6.767, p=0.007; OR 3.514, 95% CI 1.485 to 8.316, p=0.004, respectively) and ε2/ε4 was associated with all three factors (SAH: OR 7.599, 95% CI 1.764 to 32.734, p=0.006; FLP: OR 20.333, 95% CI 3.278 to 126.137, p=0.001; SAE+FLP: OR 30.568, 95% CI 4.460 to 209.503, p<0.001) after adjusting for age, and remained significant after adjusting for age and ICH volume.

Conclusion: In patients with spontaneous supratentorial ICH, APOE ε2 and ε4 alleles were associated with SAE and FLP, respectively, suggesting APOE allele-specific effects on CT markers of CAA and their potential mechanisms.

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自发性脑出血患者的 APOE 基因型与脑淀粉样血管病 CT 标记的关系

背景和目的：我们研究了 APOE 等位基因与基于 CT 的脑淀粉样血管病（CAA）标记物（包括蛛网膜下腔扩展（SAE）和指样投影（FLP））的相关性：我们纳入了中国多中心队列中的急性原发性颅内出血（ICH）患者。首先，评估了 APOE 与 ICH 位置（脑叶与非脑叶）的关系。接着，评估了 APOE 与 SAE、FLP 以及两者共存（SAE+FLP）的关系：结果：共纳入 533 名脑室上 ICH 患者。结果：共纳入 533 名脑室上 ICH 患者，其中包括 138 名大叶 ICH 患者和 395 名非大叶 ICH 患者。与非叶状 ICH 组相比，APOE ε4（OR 1.894，95% CI 1.138 至 3.154，p=0.014）和 ε2/ε4（OR 6.098，95% CI 1.414 至 26.293，p=0.015）与叶状 ICH 相关。在 CAA 标记方面，APOE ε2 与 SAE 相关（OR 2.109，95% CI 1.167 至 3.810，p=0.013），ε4 与 FLP 和 SAE+FLP 相关（OR 3.026，95% CI 1.353 至 6.767，p=0.007；OR 3.514，95% CI 1.485 至 8.316，p=0.004），而ε2/ε4与所有三个因素相关（SAH：OR 7.599，95% CI 1.764~32.734，p=0.006；FLP：OR 20.333，95% CI 3.278~126.137，p=0.001；SAE+FLP：OR 30.568，95% CI 4.460~209.503，p结论：在自发性脑室上ICH患者中，APOE ε2和ε4等位基因分别与SAE和FLP相关，这表明APOE等位基因对CAA的CT标记物有特异性影响及其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative Medicine MEDICINE, GENERAL & INTERNALMEDICINE, RESE-MEDICINE, RESEARCH & EXPERIMENTAL

自引率

0.00%

发文量

111

期刊介绍： Journal of Investigative Medicine (JIM) is the official publication of the American Federation for Medical Research. The journal is peer-reviewed and publishes high-quality original articles and reviews in the areas of basic, clinical, and translational medical research. JIM publishes on all topics and specialty areas that are critical to the conduct of the entire spectrum of biomedical research: from the translation of clinical observations at the bedside, to basic and animal research to clinical research and the implementation of innovative medical care.