Impact of Probiotics and Prebiotics on Gut Microbiome and Hormonal Regulation.

IF 0.9 Q4 GASTROENTEROLOGY & HEPATOLOGY
Jelina Basnet, Manar A Eissa, Licy L Yanes Cardozo, Damian G Romero, Samar Rezq
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Abstract

The gut microbiome plays a crucial role in human health by influencing various physiological functions through complex interactions with the endocrine system. These interactions involve the production of metabolites, signaling molecules, and direct communication with endocrine cells, which modulate hormone secretion and activity. As a result, the microbiome can exert neuroendocrine effects and contribute to metabolic regulation, adiposity, and appetite control. Additionally, the gut microbiome influences reproductive health by altering levels of sex hormones such as estrogen and testosterone, potentially contributing to conditions like polycystic ovary syndrome (PCOS) and hypogonadism. Given these roles, targeting the gut microbiome offers researchers and clinicians novel opportunities to improve overall health and well-being. Probiotics, such as Lactobacillus and Bifidobacterium, are live beneficial microbes that help maintain gut health by balancing the microbiota. Prebiotics, non-digestible fibers, nourish these beneficial bacteria, promoting their growth and activity. When combined, probiotics and prebiotics form synbiotics, which work synergistically to enhance the gut microbiota balance and improve metabolic, immune, and hormonal health. This integrated approach shows promising potential for managing conditions related to hormonal imbalances, though further research is needed to fully understand their specific mechanisms and therapeutic potential.

肠道微生物群通过与内分泌系统的复杂互动影响各种生理功能,对人体健康起着至关重要的作用。这些相互作用涉及代谢产物、信号分子的产生,以及与内分泌细胞的直接交流,从而调节激素的分泌和活性。因此,微生物群可产生神经内分泌效应,并有助于新陈代谢调节、肥胖和食欲控制。此外,肠道微生物组还会通过改变雌激素和睾酮等性激素的水平来影响生殖健康,从而可能导致多囊卵巢综合征(PCOS)和性腺功能减退症等疾病。鉴于这些作用,针对肠道微生物组的研究为研究人员和临床医生提供了改善整体健康和福祉的新机会。益生菌(如乳酸杆菌和双歧杆菌)是活的有益微生物,有助于通过平衡微生物群来维持肠道健康。益生元是一种非消化性纤维,可以滋养这些有益细菌,促进它们的生长和活动。当益生菌和益生元结合在一起时,就形成了合成益生菌,它们协同作用,增强肠道微生物群平衡,改善代谢、免疫和荷尔蒙健康。这种综合方法在控制与荷尔蒙失调有关的疾病方面显示出巨大的潜力,但要充分了解其具体机制和治疗潜力,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.50
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0.00%
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