Association between the sEH rs751141 polymorphism and the risk of ischemic stroke and hypertension: A systematic review and meta-analysis

IF 2 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2025-01-01 DOI:10.1016/j.jstrokecerebrovasdis.2024.108176

Zongshan Fan , Zidong Mao , Mengya Liu , Bingbing Fu , Xiao Yuan , Lai Wang

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引用次数: 0

Abstract

Objective

To systematically evaluate the association between the rs751141 polymorphism in soluble epoxide hydrolase (sEH) and the risk of ischemic stroke and hypertension.

Methods

We searched PubMed, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Chongqing VIP for eligible studies published through March 2024. Studies were selected based on inclusion and exclusion criteria. The quality of included studies was assessed using the Newcastle–Ottawa Scale (NOS) and Joanna Briggs Institute (JBI) tools. Data extraction and meta-analysis were performed using STATA software version 12.

Results

Twelve case-control studies were included, seven investigating the association of sEH rs751141 polymorphism with ischemic stroke risk, and five examining its association with hypertension risk. The pooled odds ratios (OR) and 95% confidence intervals for the allelic, dominant, and recessive models of ischemic stroke risk were 1.167 (1.045–1.303, p = 0.006), 1.381 (1.104–1.883, p = 0.041), and 0.856 (0.753–0.9751, p = 0.019), respectively. For hypertension risk, the pooled OR values and 95% confidence intervals were 1.343 (1.229–1.467, p < 0.001), 1.537 (1.254–1.885, p < 0.001), and 0.715 (0.64-0.80, p < 0.001), respectively.

Conclusion

Carriers of the G allele of the sEH rs751141 polymorphism are at an increased risk for ischemic stroke and hypertension, while the A allele appears to have a protective effect against these conditions.

查看原文本刊更多论文

sEH rs751141多态性与缺血性卒中和高血压风险之间的关系：一项系统综述和荟萃分析

目的：系统评价可溶性环氧化物水解酶（sEH） rs751141多态性与缺血性脑卒中和高血压风险的关系。方法：我们检索PubMed、Cochrane中央对照试验注册库、中国知网（CNKI）、万方数据和重庆VIP，检索截至2024年3月发表的符合条件的研究。根据纳入和排除标准选择研究。纳入研究的质量采用纽卡斯尔-渥太华量表（NOS）和乔安娜布里格斯研究所（JBI）工具进行评估。采用STATA软件进行数据提取和meta分析。结果：纳入12项病例对照研究，7项研究sEH rs751141多态性与缺血性卒中风险的关系，5项研究其与高血压风险的关系。等位基因模型、显性模型和隐性模型的合并优势比（OR）和95%置信区间分别为1.167 （1.045 ~ 1.303,p=0.006）、1.381 （1.104 ~ 1.883,p=0.041）和0.856 （0.753 ~ 0.9751,p=0.019）。对于高血压风险，合并OR值和95%置信区间为1.343（1.229-1.467）。结论：sEH rs751141多态性的G等位基因携带者患缺血性卒中和高血压的风险增加，而A等位基因似乎对这些疾病有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.