Complete pathological response after neoadjuvant chemotherapy and the benefit of subsequent surgery in oligometastatic pancreatic cancer patient.

Q4 Medicine
A Langer, M Loveček, O Urban, D Kurfúrstová, R Kovář, B Mohelníková Duchoňová
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引用次数: 0

Abstract

Introduction: Pancreatic cancer is one of the most aggressive tumors diagnosed in local-ly advanced or metastatic stage in more than half of the cases. The standard of care is a systemic chemotherapy but the prognosis of metastatic patients remains extremely poor with a median overall survival less than one year.  However, there is increasing evidence of surgery treatment benefit in a carefully selected oligometastatic cases.  -Because oligometastatic pancreatic cancer is rare, there is a lack of robust clinical trials defining strategy, efficacy and safety of this procedure.

Patient concerns: A 77-year-old man presented with a mass in the tail of the pancreas and solitary liver metastasis. After four cycles of chemotherapy, distal pancreatectomy with liver metastasectomy was performed, and the tissues were histologically examined. The complete pathological response was found in the primary tumor and residual adenocarcinoma in liver metastasis.

Outcomes: The patient is alive without recurrency more than two years from the diagnosis.

少转移性胰腺癌患者新辅助化疗后的完全病理反应及后续手术的益处。
简介:胰腺癌是最具侵袭性的肿瘤之一,超过一半的病例诊断为局部晚期或转移期。治疗的标准是全身化疗,但转移性患者的预后仍然非常差,中位总生存期不到一年。然而,越来越多的证据表明,在精心挑选的少转移病例中,手术治疗是有益的。由于少转移性胰腺癌是罕见的,缺乏强有力的临床试验来确定该手术的策略、有效性和安全性。患者关注:77岁男性,胰腺尾部有肿块,单发肝转移。化疗4个周期后,行远端胰切除术合并肝转移瘤切除术,并对组织进行组织学检查。原发肿瘤有完全的病理反应,肝转移的残余腺癌有完全的病理反应。结果:患者自诊断后存活2年以上无复发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Rozhledy v Chirurgii
Rozhledy v Chirurgii Medicine-Medicine (all)
CiteScore
0.50
自引率
0.00%
发文量
67
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