Prevalence of thrombosis in patients undergoing dialysis treatment: A systematic review and meta-analysis

IF 1.1 Q3 NURSING

Journal of Vascular Nursing Pub Date : 2024-12-01 DOI:10.1016/j.jvn.2024.08.003

Parisa Shiri , Shabab Rezaeian , Alireza Abdi , Alireza Khatony

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引用次数: 0

Abstract

Aim

to determine the prevalence of thrombosis in dialysis patients.

Background

Thrombosis is the most common cause of vascular access dysfunction in dialysis patients. Various studies have reported different prevalence rates of thrombosis, and no systematic study provides a comprehensive result on this subject.

Methods

In this systematic review and meta-analysis, a search of available texts was conducted until the end of December 2023, using keywords such as Thrombosis, end-stage renal disease, end-stage kidney disease, hemodialysis, and dialysis in databases including Web of Science, PubMed, Scopus, ProQuest, Ovid, Science Direct, Clinical Key, EMBASE, CINAHL, SID, and MagIran. The random-effects model was used, and the heterogeneity of the studies was assessed using the I² index. The quality of the selected studies was evaluated using the STROBE checklist. Meta-analysis was performed using CMA version 2 and STATA version 14 software. The study adhered to the guidelines stated in the PRISMA statement.

Results

Out of 12,604 articles found, after removing duplicates and conducting evaluations, the full text of 415 articles was examined, and ultimately, 141 articles were included in the study. The overall prevalence of thrombosis was 14.2% (95% CI: 11.5–17.2). The prevalence of thrombosis was higher in dialysis patients under 50 years of age (17.1%, 95% CI: 11.3–23.8) and patients with vascular access (16.2%, 95% CI: 13.1–19.5), especially arteriovenous grafts (22.8%, 95% CI: 14.5–32.4). Additionally, the prevalence of late thrombosis was higher than that of early thrombosis (15.0% vs. 5.3%) (95% CI: 7.7–24.2 vs. 95% CI: 2.7–8.5).

Conclusions

The results indicate a relatively high prevalence of thrombosis in dialysis patients. The prevalence of thrombosis in patients with arteriovenous grafts was notable. Considering the risks of thrombosis, the adoption of preventive measures in hemodialysis patients, such as the use of anticoagulant drugs, is recommended.

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透析治疗患者血栓形成的患病率：系统回顾和荟萃分析。

目的：了解透析患者血栓形成情况。背景：血栓形成是透析患者血管通路功能障碍的最常见原因。各种研究报告了不同的血栓患病率，但没有系统的研究提供全面的结果。方法：在本系统综述和荟萃分析中，使用Web of Science、PubMed、Scopus、ProQuest、Ovid、Science Direct、Clinical Key、EMBASE、CINAHL、SID和MagIran等数据库中的关键词，检索到2023年12月底的可用文献。采用随机效应模型，采用I2指数评价研究的异质性。使用STROBE检查表对所选研究的质量进行评估。采用CMA version 2和STATA version 14软件进行meta分析。该研究遵循PRISMA声明中规定的指导方针。结果：在发现的12604篇文章中，剔除重复并进行评估后，对415篇文章进行了全文审查，最终纳入141篇文章。血栓的总患病率为14.2% （95% CI: 11.5-17.2）。血栓发生率在50岁以下透析患者（17.1%,95% CI: 11.3-23.8）和血管通路患者（16.2%,95% CI: 13.1-19.5）中较高，尤其是动静脉移植患者（22.8%,95% CI: 14.5-32.4）。此外，晚期血栓发生率高于早期血栓发生率（15.0% vs. 5.3%）（95% CI: 7.7 ~ 24.2 vs. 95% CI: 2.7 ~ 8.5）。结论：透析患者血栓形成的发生率较高。动静脉移植物患者血栓形成的发生率显著。考虑到血栓形成的风险，建议血液透析患者采取预防措施，如使用抗凝药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular Nursing NURSING-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Journal of Vascular Nursing provides clinical information regarding aortic and peripheral aneurysms, upper and lower extremity arterial disease, acute and chronic venous disease, and more. Original, peer-reviewed articles present descriptions, etiologies, diagnostic procedures, medical and surgical treatment and nursing implications of vascular system disorders.