Innocent Ijezie Chukwuonye, Onoja M Akpa, Osahon Asowata, Adekunle Gregory Fakunle, Morenikeji A Komolafe, Odun Joshua Akinyemi, Fred Stephen Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Lukman Owolabi, Godwin Osaigbovo, Akinkunmi Okekunle, Okechukwu Ogah, Hemant Tiwari, Carolyn Jenkins, Bimbola Fawale, Donna Arnett, Benedict Calys-Tagoe, Abimbola Olalere, Oladimeji Adebayo, Wisdom Oguike, Philip Adebayo, Oyedunni Arulogun, Lambert Appiah, Phillip O Ibinaiye, Sunday Adeniyi, Oladotun Olalusi, Olayemi Balogun, Rufus Akinyemi, Bruce Ovbiagele, Mayowa Owolabi
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引用次数: 0
Abstract
Background: The aim of the study was to examine the association between alcohol consumption and stroke in Nigeria and Ghana.
Methods: The study is a multicentre, case-control study. Cases included consenting adults 18 years of age and older with acute stroke. The controls were age- and gender-matched, stroke-free adults. Alcohol consumption was self-reported. The participants were classified into three alcohol-drinking status groups, which included abstainers, former drinkers, and current drinkers. The current drinkers were further classified into different alcohol drinking levels, including infrequent drinkers, light drinkers, moderate drinkers, heavy drinkers, and binge drinkers. Conditional logistic regression was used to determine associations between the drinkers' status and stroke, respectively, as well as the association between the different levels of current drinkers and strokes, respectively. Five models were evaluated. Model 1 was unadjusted. Model 2 had adjustments for demographic characteristics. Model 3 included Model 2, lifestyle and psychosocial function adjustments. Model 4 includes Model 3 and dietary factor adjustments. Model 5 included Model 4 and metabolic factor adjustments.
Results: A total of 7,368 participants took part in the study. Half were stroke participants, and half were control participants. On the associations between drinking status and strokes, respectively, former drinkers showed no significant association with strokes; however, there were significant associations between current drinkers and strokes in models 1 and 2, and the odds ratio of stroke risk was 1.19 (95% CI: 1.04-1.38; p<0.05) and 1.17 (95% CI: 1.01-1.36; p<0.05), respectively. Regarding the various levels of current drinkers and their association with stroke, no significant association was observed between light drinkers and stroke in model 5. In contrast, moderate drinkers, binge drinkers, and heavy drinkers showed a persistent and significant association with stroke, respectively.
Conclusion: There is a significant association between strokes and current alcohol consumption, especially among heavy, binge, and moderate drinkers.
期刊介绍：
The International Journal of Stroke is a welcome addition to the international stroke journal landscape in that it concentrates on the clinical aspects of stroke with basic science contributions in areas of clinical interest. Reviews of current topics are broadly based to encompass not only recent advances of global interest but also those which may be more important in certain regions and the journal regularly features items of news interest from all parts of the world. To facilitate the international nature of the journal, our Associate Editors from Europe, Asia, North America and South America coordinate segments of the journal.
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