Targeted medical therapies for vascular anomalies.

IF 2.9 3区 教育学 Q1 EDUCATION, SCIENTIFIC DISCIPLINES
Alexandra Borst
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引用次数: 0

Abstract

The last 2 decades of genetic discovery in the field of vascular anomalies have brought targeted medical therapies to the forefront of care patients with vascular anomalies and have broadened the role of hematologists/oncologists in this field. Many vascular anomalies have now been identified to be driven by somatic gain-of-function variants in the PI3K/AKT/ mTOR and Ras/MAPK intracellular signaling pathways. This has led to the introduction of various antiangiogenic agents that inhibit these pathways. Knowledge of the indications for and the safe administration of these agents in patients with vascular anomalies is now a crucial part of training for hematologists/oncologists.

血管异常的靶向医学治疗。
在过去的20年里,血管异常领域的基因发现将有针对性的医学治疗带到了血管异常患者护理的前沿,并扩大了血液学家/肿瘤学家在这一领域的作用。许多血管异常现在已经确定是由PI3K/AKT/ mTOR和Ras/MAPK细胞内信号通路中的体细胞功能获得变异驱动的。这导致引入各种抑制这些途径的抗血管生成药物。血管异常患者的适应症和这些药物的安全使用知识现在是血液学家/肿瘤学家培训的重要组成部分。
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来源期刊
Hematology. American Society of Hematology. Education Program
Hematology. American Society of Hematology. Education Program EDUCATION, SCIENTIFIC DISCIPLINES-HEMATOLOGY
CiteScore
4.70
自引率
3.30%
发文量
0
期刊介绍: Hematology, the ASH Education Program, is published annually by the American Society of Hematology (ASH) in one volume per year.
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