Response of health-related quality of life following pediatric/congenital cardiac catheterization procedures

IF 3.7 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

American heart journal Pub Date : 2024-12-04 DOI:10.1016/j.ahj.2024.11.017

Michael L. O'Byrne MD, MSCE , Priya Sharma PhD , Jing Huang PhD , Christopher L. Smith MD, PhD , Jie Tang MD , Ryan Callahan MD , Jonathan B. Edelson MD , Yoav Dori MD, PhD , Matthew J. Gillespie MD , Jonathan J. Rome MD , Andrew C. Glatz MD, MSCE

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引用次数: 0

Abstract

Background

Health related quality of life (HRQOL) is a patient-reported metric (PRM) that provides a holistic measure of health that is not addressed in traditional outcome measures. The acute responsiveness of HRQOL after pediatric/congenital cardiac catheterization procedures has not, to our knowledge, been studied.

Methods

A single-center prospective cohort study was performed, longitudinally evaluating HRQOL and other PRM in school-age children and adolescents (ages 8-18) undergoing diagnostic and interventional cardiac catheterization procedures prior to their scheduled procedure, and then 1 day, ∼1 month, and ∼3 months after the procedure. Differences between HRQOL at baseline and at 1- and 3-month follow-up were evaluated using paired Student's t-tests.

Results

A total of 70 patient-parent/guardian dyads were studied. The participating patients were 13±3 years old, 51% female, and 74% non-Hispanic white, with 54% undergoing a diagnostic procedure. The trajectory of cardiac-specific HRQOL as measured through Pediatric Cardiac Quality of Life Inventory differed for patients undergoing diagnostic and interventional procedures. Following diagnostic procedures, there was no significant change in cardiac-specific HRQOL (P > .05). After interventional procedures, patient-reported cardiac-specific HRQOL increased at both 1-month (4.3±11, P = .04) and 3-months (5.9±11.4, P = .02), though the same changes were not seen in parent/guardian-reported cardiac-specific HRQOL (P > .05). PROMIS measures of physical function, psychological symptoms, and social function were associated with baseline cardiac-specific HRQOL (all P < .05), but no associations were seen between other patient-reported outcomes and baseline HRQOL or change from baseline to 3-month follow-up.

Conclusion

Across a range of transcatheter interventional procedures, patient-reported cardiac-specific HRQOL improved in short term follow up, though these changes were not seen in parent/guardian reported measures. Incorporating these patient-centered metrics into evaluation of transcatheter therapies may provide more accurate measures of comparative effectiveness.

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儿童/先天性心导管置入术后健康相关生活质量的反应

背景：健康相关生活质量（HRQOL）是一种患者报告的指标（PRM），它提供了传统结果测量方法无法解决的整体健康测量。据我们所知，尚未对儿童/先天性心导管置入术后HRQOL的急性反应性进行研究。方法：进行了一项单中心前瞻性队列研究，纵向评估学龄儿童和青少年（8-18岁）在预定手术前接受诊断性和介入性心导管手术，然后在手术后1天、1个月和3个月进行HRQOL和其他PRM。采用配对学生t检验评估基线时与随访1个月和3个月时HRQOL的差异。结果：共对70对患者-父母/监护人进行了研究。参与研究的患者年龄为13±3岁，51%为女性，74%为非西班牙裔白人，其中54%接受了诊断程序。通过儿童心脏生活质量量表测量的心脏特异性HRQOL的轨迹在接受诊断和介入性手术的患者中有所不同。在诊断程序后，心脏特异性HRQOL无显著变化（p < 0.05）。介入手术后，患者报告的心脏特异性HRQOL在1个月（4.3±11,p=0.04）和3个月（5.9±11.4,p=0.02）均有所增加，但在父母/监护人报告的心脏特异性HRQOL中未见相同变化（p < 0.05）。PROMIS测量的身体功能、心理症状和社会功能与基线心脏特异性HRQOL相关。结论：在一系列经导管介入手术中，患者报告的心脏特异性HRQOL在短期随访中得到改善，尽管这些变化在父母/监护人报告的测量中未见。将这些以患者为中心的指标纳入经导管治疗的评估中，可以提供更准确的相对有效性衡量标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American heart journal 医学-心血管系统

CiteScore

8.20

自引率

2.10%

发文量

214

审稿时长

38 days

期刊介绍： The American Heart Journal will consider for publication suitable articles on topics pertaining to the broad discipline of cardiovascular disease. Our goal is to provide the reader primary investigation, scholarly review, and opinion concerning the practice of cardiovascular medicine. We especially encourage submission of 3 types of reports that are not frequently seen in cardiovascular journals: negative clinical studies, reports on study designs, and studies involving the organization of medical care. The Journal does not accept individual case reports or original articles involving bench laboratory or animal research.