Unveiling KLHL23 as a key immune regulator in hepatocellular carcinoma through integrated analysis.

IF 3.9 3区医学 Q2 CELL BIOLOGY

Aging-Us Pub Date : 2024-12-04 DOI:10.18632/aging.206167

Liangliang Xu, Bo Li, Yuchen Liu, Zhengming Hu, Qing Dan, Bingxuan Xu, Hongjin Xiang, Yun Chen, Tingting Zheng, Desheng Sun, Li Liu

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Abstract

Age-related cancers are characterized by impaired protein homeostasis, where Kelch protein superfamily members have showed accumulating clues as critical regulators. In this paper, the cancerous role of Kelch-like family member 23 (KLHL23) was comprehensively analyzed with TCGA and single cell GEO database across overall 33 cancer types. By multi-omics analysis upon the transcriptomic, genomic, and methylation data, the current study explored the association of KLHL23 with patient survival, gene ontology, tumor-infiltrating lymphocytes, and drug responses. The correlation of copy number variations and methylation with dysregulated expression of KLHL23 were also addressed. Notably, KLHL23 levels correlated with survival in cancers such as hepatocellular carcinoma and low-grade glioma. The study also highlighted how reduced KLHL23 expression is linked to increased immune activity and sensitivity to chemotherapy, suggesting its potential as a biomarker for cancer prognosis and treatment responsiveness.

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通过综合分析揭示KLHL23作为肝细胞癌的关键免疫调节因子。

年龄相关癌症的特征是蛋白质稳态受损，Kelch蛋白超家族成员已经显示出作为关键调节因子的积累线索。本文利用TCGA和单细胞GEO数据库综合分析kelch样家族成员23 （KLHL23）在33种肿瘤类型中的癌变作用。本研究通过转录组学、基因组学和甲基化数据的多组学分析，探讨了KLHL23与患者生存、基因本体、肿瘤浸润淋巴细胞和药物反应的关系。拷贝数变化和甲基化与KLHL23表达失调的相关性也得到了解决。值得注意的是，KLHL23水平与肝癌和低级别胶质瘤等癌症的生存率相关。该研究还强调了KLHL23表达减少如何与免疫活性增加和化疗敏感性相关，这表明它有可能作为癌症预后和治疗反应性的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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