MRI analysis of relative tumor enhancement in liver metastases and correlation with immunohistochemical features.

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2024-12-05 DOI:10.1186/s13244-024-01866-7

Felix Barajas Ordonez, Sebastian Gottschling, Kai Ina Eger, Jan Borggrefe, Dörthe Jechorek, Alexey Surov

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引用次数: 0

Abstract

Objective: Investigate the association between the relative tumor enhancement (RTE) of gadoxetic acid across various MRI phases and immunohistochemical (IHC) features in patients with liver metastases (LM) from colorectal cancer (CRC), breast cancer (BC), and pancreatic cancer (PC).

Methods: A retrospective analysis was conducted on 68 patients with LM who underwent 1.5-T MRI scans. Non-contrast and contrast-enhanced T1-weighted (T1-w) gradient echo (GRE) sequences were acquired before LM biopsy. RTE values among LM groups were compared by cancer type using analysis of variance. The relationships between RTE and IHC features tumor stroma ratio, cell count, Ki67 proliferation index, and CD45 expression were evaluated using Spearman's rank correlation coefficients.

Results: Significant differences in RTE were observed across different MRI phases among patients with BCLM, CRCLM, and PCLM: arterial phase (0.75 ± 0.42, 0.37 ± 0.36, and 0.44 ± 0.19), portal venous phase (1.09 ± 0.41, 0.59 ± 0.44, and 0.53 ± 0.24), and venous phase (1.11 ± 0.45, 0.65 ± 0.61, and 0.50 ± 0.20). In CRCLM, RTE inversely correlated with mean Ki67 (r = -0.50, p = 0.01) in the hepatobiliary phase. Negative correlations between RTE and CD45 expression were found in PCLM and CRCLM in the portal venous phase (r = -0.69, p = 0.01 and r = -0.41, p = 0.04) and the venous phase (r = -0.65, p = 0.01 and r = -0.44, p = 0.02).

Conclusion: Significant variations in RTE were identified among different types of LM, with correlations between RTE values and IHC markers such as CD45 and Ki67 suggesting that RTE may serve as a non-invasive biomarker for predicting IHC features in LM.

Critical relevance statement: RTE values serve as a predictive biomarker for IHC features in liver metastasis, potentially enhancing non-invasive patient assessment, disease monitoring, and treatment planning.

Key points: Few studies link gadoxetic acid-enhanced MRI with immunohistochemistry in LM. RTE varies by liver metastasis type and correlates with CD45 and Ki67. RTE reflects IHC features in LM, aiding non-invasive assessment.

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肝转移灶相对肿瘤强化的MRI分析及其与免疫组织化学特征的相关性。

目的：探讨结直肠癌（CRC）、乳腺癌（BC）和胰腺癌（PC）肝转移（LM）患者不同MRI期gadoxetic酸相对肿瘤增强（RTE）与免疫组化（IHC）特征的关系。方法：对68例行1.5 t MRI扫描的LM患者进行回顾性分析。在LM活检前获得非对比和增强t1加权（T1-w）梯度回声（GRE）序列。采用方差分析比较LM组间肿瘤类型的RTE值。采用Spearman秩相关系数评价RTE与IHC特征间质比、细胞计数、Ki67增殖指数、CD45表达的关系。结果：BCLM、CRCLM、PCLM患者的RTE在不同MRI期有显著差异：动脉期（0.75±0.42、0.37±0.36、0.44±0.19）、门静脉期（1.09±0.41、0.59±0.44、0.53±0.24）、静脉期（1.11±0.45、0.65±0.61、0.50±0.20）。在CRCLM中，肝胆期RTE与平均Ki67呈负相关（r = -0.50, p = 0.01）。PCLM和CRCLM在门静脉期（r = -0.69, p = 0.01, r = -0.41, p = 0.04）和静脉期（r = -0.65, p = 0.01, r = -0.44, p = 0.02） RTE与CD45表达呈负相关。结论：RTE在不同类型LM中存在显著差异，RTE值与免疫组化标志物如CD45和Ki67之间存在相关性，提示RTE可作为预测LM免疫组化特征的非侵入性生物标志物。关键相关性声明：RTE值可作为肝转移中免疫组化特征的预测性生物标志物，潜在地增强非侵入性患者评估、疾病监测和治疗计划。重点：很少有研究将加多己酸增强MRI与LM的免疫组织化学联系起来。RTE因肝转移类型而异，并与CD45和Ki67相关。RTE反映了LM的免疫组化特征，有助于非侵入性评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.