{"title":"The influence of sex and age differences in an adult zebrafish (Danio rerio) T-maze model of cognition.","authors":"Ji-Hang Yin, Katharine A Horzmann","doi":"10.1111/jfb.16024","DOIUrl":null,"url":null,"abstract":"<p><p>The zebrafish (Danio rerio) model is increasingly popular in neurobehavioral research, and behavioral outcomes are commonly evaluated in studies on neurodegeneration and neurotoxicity. Sex and age have been identified as important variables in cognition studies; however, these factors are often underreported in published studies that use the zebrafish model, leading to uncertainty about their impact in zebrafish T-maze experiments. In this study, we evaluated the role of sex and age in zebrafish cognitive function using a 5-day T-maze task. Our results demonstrated that female and younger zebrafish had increased learning and memory capacity. These findings highlighted the importance of considering and reporting sex and age in experimental design in zebrafish cognitive neurobehavioral studies.</p>","PeriodicalId":15794,"journal":{"name":"Journal of fish biology","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of fish biology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/jfb.16024","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FISHERIES","Score":null,"Total":0}
引用次数: 0
Abstract
The zebrafish (Danio rerio) model is increasingly popular in neurobehavioral research, and behavioral outcomes are commonly evaluated in studies on neurodegeneration and neurotoxicity. Sex and age have been identified as important variables in cognition studies; however, these factors are often underreported in published studies that use the zebrafish model, leading to uncertainty about their impact in zebrafish T-maze experiments. In this study, we evaluated the role of sex and age in zebrafish cognitive function using a 5-day T-maze task. Our results demonstrated that female and younger zebrafish had increased learning and memory capacity. These findings highlighted the importance of considering and reporting sex and age in experimental design in zebrafish cognitive neurobehavioral studies.
期刊介绍：
The Journal of Fish Biology is a leading international journal for scientists engaged in all aspects of fishes and fisheries research, both fresh water and marine. The journal publishes high-quality papers relevant to the central theme of fish biology and aims to bring together under one cover an overall picture of the research in progress and to provide international communication among researchers in many disciplines with a common interest in the biology of fish.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
