Evaluation of the value of dynamic contrast-enhanced MRI for the diagnosis and follow-up of central cartilage tumors

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-02-01 DOI:10.1016/j.ejrad.2024.111860

Maryse Lejoly , Thomas Van Den Berghe , Felix Delbare , Wouter C.J. Huysse , David Creytens , Gwen Sys , Koenraad L. Verstraete

{"title":"Evaluation of the value of dynamic contrast-enhanced MRI for the diagnosis and follow-up of central cartilage tumors","authors":"Maryse Lejoly , Thomas Van Den Berghe , Felix Delbare , Wouter C.J. Huysse , David Creytens , Gwen Sys , Koenraad L. Verstraete","doi":"10.1016/j.ejrad.2024.111860","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the value of (dynamic) contrast-enhanced MRI for the diagnosis and follow-up of central cartilage tumors (CCT) of the proximal humerus, distal femur and proximal tibia.</div></div><div><h3>Materials & methods</h3><div>97 patients (44 ± 11 years, 31men) with a CCT (histopathologically proven and/or > 2 years follow-up (5 ± 3 years)) were retrospectively/consecutively included at the Ghent University Hospital (Belgium, 2003–2021). Thickness of the enhancing rim and dynamic contrast-enhanced MRI parameters of the entire tumor were calculated. Tumor volumes were calculated to assess tumor growth. Significant differences between enchondromas, atypical cartilaginous tumors, high-grade chondrosarcomas, tumors with and without growth at follow-up were evaluated and ROC-curves were analyzed.</div></div><div><h3>Results</h3><div>A significant difference (p = 0.015) existed in enhancing rim thickness between high-grade chondrosarcomas and other groups. A ROC-curve with an AUC of 0.89 and cut-off value of 1.2 mm had a sensitivity of 100 % and a specificity of 64 % to identify high-grade chondrosarcomas. A significant correlation was found between the relative maximal enhancement (Rel-Emax) of the whole tumor compared to muscle and the absolute growth rate (ρ = 0.75, p < 0.001). Lesions with a Rel-Emax < 1 remained stable or showed regression during follow-up (mean −0.1 ± 0.3 ml/year). Lesions with a Rel-Emax between 1 and 2 showed little growth (mean + 0.2 ± 0.2 ml/year), and lesions with a Rel-Emax > 2 had the highest growth rate (mean 0.4 ± 0.2 ml/year).</div></div><div><h3>Conclusion</h3><div>A thick enhancing rim > 1.2 mm has a high sensitivity to detect high-grade chondrosarcomas. The higher the Rel-Emax of the whole tumor compared to muscle, the higher the growth rate of a CCT.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111860"},"PeriodicalIF":3.2000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0720048X2400576X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

To evaluate the value of (dynamic) contrast-enhanced MRI for the diagnosis and follow-up of central cartilage tumors (CCT) of the proximal humerus, distal femur and proximal tibia.

Materials & methods

97 patients (44 ± 11 years, 31men) with a CCT (histopathologically proven and/or > 2 years follow-up (5 ± 3 years)) were retrospectively/consecutively included at the Ghent University Hospital (Belgium, 2003–2021). Thickness of the enhancing rim and dynamic contrast-enhanced MRI parameters of the entire tumor were calculated. Tumor volumes were calculated to assess tumor growth. Significant differences between enchondromas, atypical cartilaginous tumors, high-grade chondrosarcomas, tumors with and without growth at follow-up were evaluated and ROC-curves were analyzed.

Results

A significant difference (p = 0.015) existed in enhancing rim thickness between high-grade chondrosarcomas and other groups. A ROC-curve with an AUC of 0.89 and cut-off value of 1.2 mm had a sensitivity of 100 % and a specificity of 64 % to identify high-grade chondrosarcomas. A significant correlation was found between the relative maximal enhancement (Rel-Emax) of the whole tumor compared to muscle and the absolute growth rate (ρ = 0.75, p < 0.001). Lesions with a Rel-Emax < 1 remained stable or showed regression during follow-up (mean −0.1 ± 0.3 ml/year). Lesions with a Rel-Emax between 1 and 2 showed little growth (mean + 0.2 ± 0.2 ml/year), and lesions with a Rel-Emax > 2 had the highest growth rate (mean 0.4 ± 0.2 ml/year).

Conclusion

A thick enhancing rim > 1.2 mm has a high sensitivity to detect high-grade chondrosarcomas. The higher the Rel-Emax of the whole tumor compared to muscle, the higher the growth rate of a CCT.

Abstract Image

查看原文本刊更多论文

动态增强MRI对中央软骨肿瘤的诊断及随访价值评价。

目的：探讨（动态）增强MRI对肱骨近端、股骨远端和胫骨近端中央软骨肿瘤（CCT）的诊断和随访价值。材料与方法：回顾性/连续纳入比利时根特大学医院（2003-2021）97例（44±11岁，31例男性）CCT患者（经组织病理学证实和/或随访2年（5±3年））。计算整个肿瘤的增强边缘厚度和动态增强MRI参数。计算肿瘤体积以评估肿瘤生长情况。评估内生性软骨瘤、非典型软骨瘤、高级别软骨肉瘤、有无生长肿瘤的随访差异，并分析roc曲线。结果：高级别软骨肉瘤组与其他组在增强骨缘厚度方面存在显著差异（p = 0.015）。roc曲线的AUC为0.89，截断值为1.2 mm，识别高级别软骨肉瘤的敏感性为100%，特异性为64%。全肿瘤相对于肌肉的相对最大增强（Rel-Emax）与绝对生长率有显著相关(ρ = 0.75， p 2的生长率最高（平均0.4±0.2 ml/年）。结论：1.2 mm厚增强边缘>对高级别软骨肉瘤有较高的检测灵敏度。与肌肉相比，整个肿瘤的Rel-Emax越高，CCT的生长速度越快。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.