Incremental Cardiovascular Risk of Menopause in Women with Psoriasis, Psoriatic Arthritis or Spondyloarthritis?

IF 5.7 2区医学 Q1 RHEUMATOLOGY

Current Rheumatology Reports Pub Date : 2024-12-06 DOI:10.1007/s11926-024-01169-2

Donna E Vegt, Delia A Popa-Diaconu, Michelle L M Mulder, Sander I van Leuven, Irene E van der Horst-Bruinsma

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Abstract

Purpose of the review: This narrative review aims to discuss the most recent studies regarding the risk of cardiovascular disease (CVD) in women with psoriasis, psoriatic arthritis (PsA) and spondyloarthritis (SpA). In addition, the potential of menopause to modulate/increase CVD risk in women with these diseases will also be explored. It is of major interest to gain more understanding into this topic because it can have meaningful implications for screening and treatment of CVD risk in these women.

Recent findings: Literature shows that psoriasis, PsA, SpA and menopause itself cause higher CVD risks and higher CVD prevalence. This is predominantly explained by the increase of chronic systemic inflammation. No existing literature conclusively demonstrates or studies specifically whether the menopause amplifies this effect caused by psoriasis, PsA, or SpA.

Conclusion: Differences in pathophysiology of psoriasis, SpA and PsA versus the menopausal transition could suggest that menopause may increase the risk of CVD. However, the hypothesis that menopause represents an additional CV risk factor in women with psoriasis, PsA and SpA still needs to be thoroughly investigated and more clinical studies are required for further understanding and conclusions.

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银屑病、银屑病关节炎或脊柱炎女性绝经后心血管风险增加？

综述目的：本综述旨在讨论银屑病、银屑病关节炎（PsA）和脊柱性关节炎（SpA）女性心血管疾病（CVD）风险的最新研究。此外，还将探讨更年期对患有这些疾病的妇女心血管疾病风险的调节/增加的可能性。对这一主题有更多的了解是重要的，因为它对这些妇女的心血管疾病风险的筛查和治疗具有重要意义。最新发现：文献显示牛皮癣、PsA、SpA和更年期本身会导致更高的CVD风险和更高的CVD患病率。这主要是由于慢性全身性炎症的增加。目前尚无文献结论性地论证或专门研究更年期是否会放大牛皮癣、PsA或SpA引起的这种效应。结论：银屑病的病理生理、SpA和PsA与绝经期的差异提示绝经期可能增加CVD的风险。然而，更年期是银屑病女性、PsA和SpA的另一个CV危险因素的假设仍需要深入研究，需要更多的临床研究来进一步理解和得出结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Rheumatology Reports RHEUMATOLOGY-

CiteScore

11.20

自引率

0.00%

发文量

期刊介绍： This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.