Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional study

IF 3.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-01-01 DOI:10.1016/j.aohep.2024.101759

Qiaoling Wu , Yongmei Peng , Chundan Gong

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引用次数: 0

Abstract

Introduction and Objectives

Relationships and interactions among waist circumference (WC), body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) with steatotic liver disease (SLD) in children have rarely been studied as a whole. We aimed to investigate the association among WC, BMI and hs-CRP with SLD and its related metabolic indictors.

Materials and Methods

A total of 10,776 children aged 10–15 years were screened in our study. Anthropometric data, biochemical parameters and ultrasound assessments were collected. Metabolic indictors between children with and without SLD were compared. The correlation of waist circumference Z score (ZWC), body mass index Z score (ZBMI) and hs-CRP with SLD and its related metabolic indictors, and the interactive effect between ZWC with hs-CRP and ZBMI with hs-CRP upon SLD, respectively, was tested.

Results

A total of 543 children with normal BMI (n = 287) and high BMI (n = 256) were examined. Hs-CRP, ZWC and ZBMI were all found to significantly correlate with SLD and its related metabolic indexes. The interaction effect analysis showed that ZWC and male was independent risk factor of SLD with OR (95 %CI) of 23.431 (7.253, 75.697) and 7.927 (2.766,22.713), respectively, whereas the same effect wasn't found in ZBMI. The cut-off value of ZWC for the prediction of SLD was 1.494 and 1.541 in boys and girls, respectively.

Conclusions

Increased WC, BMI and hs-CRP exerts adverse effect in pediatric SLD and its related metabolic indictors. WC and male gender could be independent risk factors for SLD, and WC was a powerful index for the prediction of SLD in children aged 10–15 years.

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腰围、体重指数和高敏c反应蛋白在小儿脂肪变性肝病中的作用：一项横断面研究

前言与目的：目前很少对儿童腰围（WC）、体重指数（BMI）和高敏c反应蛋白（hs-CRP）与脂肪变性肝病（SLD）的关系和相互作用进行整体研究。我们旨在探讨WC、BMI和hs-CRP与SLD及其相关代谢指标的关系。材料与方法：本研究共筛选10,776名10-15岁儿童。收集人体测量数据、生化参数和超声评估。比较有无SLD患儿的代谢指标。检验腰围Z评分（ZWC）、体重指数Z评分（ZBMI）、hs-CRP与SLD及其相关代谢指标的相关性，以及ZWC与hs-CRP、ZBMI与hs-CRP对SLD的交互作用。结果：共检查BMI正常儿童（n=287）和BMI高儿童（n=256） 543例。Hs-CRP、ZWC、ZBMI均与SLD及其相关代谢指标显著相关。互作效应分析显示，ZWC和男性是SLD的独立危险因素，OR （95%CI）分别为23.431（7.253,75.697）和7.927(2.766,22.713)，而ZBMI无相同影响。ZWC预测男孩和女孩SLD的临界值分别为1.494和1.541。结论：WC、BMI、hs-CRP升高对儿童SLD及其相关代谢指标有不利影响。WC和男性性别可能是SLD的独立危险因素，WC是预测10-15岁儿童SLD的有力指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.