Factors associated with obtaining lower IQR-CAP values in the detection of hepatic steatosis by transient elastography

IF 3.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-01-01 DOI:10.1016/j.aohep.2024.101762

Iván López-Mendez , Juan Luis Romero-Flores , Graciela Castro-Narro , Misael Uribe , Eva Juárez-Hernández

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Abstract

Introduction and Objectives

Controlled attenuation parameter (CAP) has been developed as a non-invasive method for detecting liver steatosis. The aim of the study was to determine factors associated with non-obtaining lower IQR-CAP values.

Materials and Methods

Retrospective revision of medical records of CAP studies for steatosis screening. Anthropometrical, biochemical, and quality variables were collected. A logistic regression analysis was performed to determine independent associations with non-obtaining IQR-CAP <30, <20, and <10 in all patients and then adjusted for obesity/overweight and severity of steatosis.

Results

5061 studies were analyzed. Median IQR-CAP was 26 [IQR 20–33] dB/m. Steatosis prevalence was 39.4 % (n = 1996). In overweight patients, significant alcohol consumption was an independent factor for non-obtaining IQR-CAP <30; meanwhile, in obese patients glucose impairment, AST, skPa>8 and steatosis severity were independent factors for non-obtaining lower IQR-CAP values. According to steatosis severity, the presence of anthropometric characteristics of obesity and significant alcohol consumption were independent factors for non-obtaining lower IQR-CAP values.

Conclusions

In steatosis detection by CAP, obesity, significant alcohol consumption, glucose impairments, and minimal liver function test alterations were independent factors associated with non-obtaining lower values of IQR-CAP.

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瞬时弹性成像在肝脂肪变性检测中获得较低IQR-CAP值的相关因素。

简介和目的：控制衰减参数（CAP）已发展成为一种检测肝脏脂肪变性的无创方法。本研究的目的是确定与未获得较低IQR-CAP值相关的因素。材料和方法：回顾性修订CAP研究中用于脂肪变性筛查的医疗记录。收集人体测量、生化和质量变量。进行逻辑回归分析以确定与未获得IQR-CAP结果的独立关联：分析了5061项研究。中位IQR- cap为26 [IQR 20-33] dB/m。脂肪变性患病率为39.4% （n =1996）。在超重患者中，大量饮酒是无法获得IQR-CAP 8的独立因素，脂肪变性严重程度是无法获得较低IQR-CAP值的独立因素。根据脂肪变性的严重程度，存在肥胖的人体测量特征和大量饮酒是未获得较低IQR-CAP值的独立因素。结论：在用CAP检测脂肪变性时，肥胖、大量饮酒、葡萄糖损伤和肝功能测试的微小改变是与IQR-CAP未获得较低值相关的独立因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.