Synthesis, structure and biological activity of new picolinohydrazonamide derivatives.

IF 0.7 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Acta Crystallographica Section C Structural Chemistry Pub Date : 2025-01-01 DOI:10.1107/S2053229624011549

Jarosław Sukiennik, Andrzej Olczak, Katarzyna Gobis, Izabela Korona-Głowniak, Katarzyna Suśniak, Andrzej Fruziński, Małgorzata Szczesio

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引用次数: 0

Abstract

Three new thiosemicarbazide derivatives are described in terms of synthesis, structure and biological activity. N'-(Morpholine-4-carbonothioyl)-4-(4-phenylpiperazin-1-yl)picolinohydrazonamide 2-methyltetrahydrofuran hemisolvate, 2C₂₁H₂₇N₇OS·C₅H₁₀O, 1, determined at 100 K, has orthorhombic (Pca2₁) symmetry and exhibits disorder. 4-(4-Phenylpiperazin-1-yl)-N'-(piperidine-1-carbonothioyl)picolinohydrazonamide-dimethylformamide-water (1/1/0.285), C₂₂H₂₉N₇S·C₃H₇NO·0.285H₂O, 2, determined at 100 K, has monoclinic (P2₁/c) symmetry. 4-(4-Phenylpiperazin-1-yl)-N'-(pyrrolidine-1-carbonothioyl)picolinohydrazonamide, C₂₁H₂₇N₇S, 3, determined at 100 K, has triclinic (P1) symmetry and exhibits disorder. Compounds 1 and 2 contain solvent molecules in their structure. All three studied compounds adopt the zwitterionic form and were tested for their microbiological activity on a model panel of Gram-positive and Gram-negative bacteria, as well as selected yeasts.

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新型吡咯酰肼酰胺衍生物的合成、结构及生物活性研究。

介绍了三种新的硫代氨基脲衍生物的合成、结构和生物活性。N′-（4-羰基）-4-（4-苯基哌嗪-1-基）picolinohydrazonamide 2-甲基四氢呋喃半磺酸盐，2C21H27N7OS·c5h100o, 1，在100 K下测定，具有正构对称（Pca21）和无序性。4-（4-苯基哌嗪-1-酰基）- n '-（哌啶-1-羰基）吡啶酰肼酰胺-二甲基甲酰胺-水（1/1/0.285），C22H29N7S·C3H7NO·0.285H2O, 2，在100 K下测定，具有单斜（P21/c）对称性。4-（4-苯基哌嗪-1-基）- n '-（吡咯烷-1-羰基）picolinohydrazonamide, C21H27N7S, 3，在100 K下测定，具有三斜（P1）对称性和无序性。化合物1和2的结构中含有溶剂分子。所有三种被研究的化合物都采用两性离子形式，并在革兰氏阳性和革兰氏阴性细菌模型面板以及选定的酵母上测试了它们的微生物活性。

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来源期刊

Acta Crystallographica Section C Structural Chemistry CHEMISTRY, MULTIDISCIPLINARYCRYSTALLOGRAPH-CRYSTALLOGRAPHY

CiteScore

1.60

自引率

12.50%

发文量

148

期刊介绍： Acta Crystallographica Section C: Structural Chemistry is continuing its transition to a journal that publishes exciting science with structural content, in particular, important results relating to the chemical sciences. Section C is the journal of choice for the rapid publication of articles that highlight interesting research facilitated by the determination, calculation or analysis of structures of any type, other than macromolecular structures. Articles that emphasize the science and the outcomes that were enabled by the study are particularly welcomed. Authors are encouraged to include mainstream science in their papers, thereby producing manuscripts that are substantial scientific well-rounded contributions that appeal to a broad community of readers and increase the profile of the authors.