PSMA PET vs. mpMRI for Lymph Node Metastasis of Prostate Cancer: A Systematic Review and Head-to-Head Comparative Meta-analysis.

IF 3.8 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Academic Radiology Pub Date : 2024-12-03 DOI:10.1016/j.acra.2024.11.029

Bin Yang, Hao Dong, Shuwei Zhang, Shaoxing Ming, Rui Yang, Yonghan Peng, Xiaofeng Gao

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引用次数: 0

Abstract

Purpose: To compare prostate-specific membrane antigen (PSMA) PET with multiparametric MRI (mpMRI) in the diagnosis of lymph node metastasis (LNM) in prostate cancer.

Methods: A comprehensive search of PubMed, Embase, and Web of Science identified studies published up to August 24, 2024. Studies comparing PSMA PET and mpMRI accuracy in detecting LNM in prostate cancer were included. The quality of each study was assessed using the Quality Assessment of Diagnostic Performance Studies-2 tool.

Results: This study included 23 articles with a total of 3041 patients. The pooled analysis showed PSMA PET had a sensitivity of 0.74 (95% CI:0.62-0.85) and specificity of 0.96 (95% CI:0.93-0.98) for detecting prostate cancer LNM, while mpMRI had a sensitivity of 0.45 (95% CI:0.32-0.57) and specificity at 0.92 (95% CI:0.86-0.97). PSMA PET shows notably higher sensitivity than mpMRI, (P < 0.01) with no significant difference in specificity (P = 0.18). For initial staging, PSMA PET shows significantly higher sensitivity than mpMRI (P < 0.01), with no significant specificity difference (P = 0.17). Subgroup analysis showed that both [⁶⁸Ga]Ga-PSMA-11 PET and [¹⁸F]F-PSMA-1007 PET had higher sensitivity than mpMRI (P = 0.03, P < 0.01) without significant differences in specificity (P = 0.10, P = 0.73). Meanwhile, there was no significant difference in the sensitivity (P = 0.20) and specificity (P = 0.43) of [¹⁸F]F-DCFPyL PET.

Conclusion: PSMA PET is more sensitive than mpMRI in detecting LNM in prostate cancer, especially for initial staging; however, there is no significant difference in specificity between the two. Due to the high heterogeneity, more subgroup-based studies are needed to standardize imaging practices and validate these findings.

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来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.