Sub-acute stroke demonstrates altered beta oscillation and connectivity pattern in working memory.

IF 5.2 2区医学 Q1 ENGINEERING, BIOMEDICAL

Journal of NeuroEngineering and Rehabilitation Pub Date : 2024-12-04 DOI:10.1186/s12984-024-01516-5

Lin Mao, Xianwei Che, Juehan Wang, Xiaorui Jiang, Yifan Zhao, Liliang Zou, Shuang Wei, Shuyi Pan, Dazhi Guo, Xueqiong Zhu, Dongxia Hu, Xiaofeng Yang, Zuobing Chen, Daming Wang

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引用次数: 0

Abstract

Introduction: Working memory (WM) is suggested to play a pivotal role in relearning and neural restoration during stroke rehabilitation. Using EEG, this study investigated the oscillatory mechanisms of WM in subacute stroke.

Methods: This study included 48 first subacute stroke patients (26 good-recovery, 22 poor-recovery, based on prognosis after a 4-week period) and 24 matched health controls. We examined the oscillatory characteristics and functional connectivity of the 0-back WM paradigm and assessed their associations with prognosis.

Results: Patients of poor recovery are characterised by a loss of significant beta rebound, beta-band connectivity, as well as impaired working memory speed and performances. Meanwhile, patients with good recovery have preserved these capacities to some extent. Our data further identified beta rebound to be closely associated with working memory speed and performances.

Conclusions: We provided novel findings that beta rebound and network connectivity as mechanistic evidence of impaired working memory in subacute stroke. These oscillatory features could potentially serve as a biomarker for brain stimulation technologies in stroke recovery.

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亚急性中风显示工作记忆的β振荡和连接模式改变。

工作记忆（Working memory， WM）被认为在脑卒中康复过程中的再学习和神经恢复中起着关键作用。利用脑电图研究亚急性脑卒中WM的振荡机制。方法：本研究纳入48例首次亚急性脑卒中患者（根据4周后的预后，26例恢复良好，22例恢复不良）和24例匹配的健康对照。我们研究了0-back WM范式的振荡特征和功能连通性，并评估了它们与预后的关系。结果：恢复差的患者的特征是显著的β反弹、β波段连通性丧失，以及工作记忆速度和表现受损。同时，康复良好的患者在一定程度上保留了这些能力。我们的数据进一步证实了贝塔反弹与工作记忆速度和表现密切相关。结论：我们提供了新的发现，β反弹和网络连接是亚急性中风中工作记忆受损的机制证据。这些振荡特征可能作为脑刺激技术在中风恢复中的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of NeuroEngineering and Rehabilitation 工程技术-工程：生物医学

CiteScore

9.60

自引率

3.90%

发文量

122

审稿时长

24 months

期刊介绍： Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.