Retroverted Uterus in the First Trimester and Associated Pregnancy Outcomes.

IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Emily R Schneider, Agata Kantorowska, Joanna M Clough, Erin L Miller, Emmanuella Kobara, Jasmine Brite, Meredith L Akerman, Wendy L Kinzler, Anju Suhag, Martin R Chavez, Patricia Rekawek
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引用次数: 0

Abstract

Objective:  This study aimed to investigate if retroverted (RV) uterus noted on nuchal translucency (NT) ultrasound is associated with second-trimester pregnancy loss and other adverse pregnancy outcomes.

Study design:  This was a retrospective cohort study of patients with RV uterus documented on NT ultrasound at a single academic medical center from October 2019 to March 2023. Subjects were identified using a query for "retroverted" uterine position within an obstetric ultrasound imaging program. For each RV case, two anteverted (AV) subjects were selected for comparison. Patients with multiple gestation, Mullerian anomalies, or fetal aneuploidy were excluded. Maternal demographics, obstetric, and neonatal outcomes were obtained by chart review. Fisher's exact test and Mann-Whitney test were used for categorical and continuous variables, respectively, with p-value <0.05 denoting significance. Multivariable logistic regression was used to adjust for possible confounding variables.

Results:  Analysis included 249 patients-83 RV and 166 AV. RV patients were more likely to identify as Caucasian (71.1 vs. 49.4%, p = 0.001), have private insurance (80.7 vs. 59.4%, p = 0.001), lower body mass index (25.4 ± 5.1 vs 29.1 ± 7.2, p < 0.001), and conceive by in vitro fertilization (IVF, 11 vs. 3%, p = 0.018). Most RV subjects (98%) had a resolution of retroversion by the second trimester. There was no difference in second-trimester pregnancy loss (0 vs. 1.2%, p = 0.55). After adjusting for race and IVF, RV subjects were four times more likely to have first-trimester vaginal bleeding (16.9 vs. 4.2%, odds ratio = 4.1, p = 0.0056). No other differences in adverse outcomes were observed.

Conclusion:  Persistent RV uterus in the first trimester is associated with increased risk of first-trimester vaginal bleeding. However, rates of pregnancy loss were similar between groups, providing valuable information for patient counseling. Significantly more RV subjects conceived by IVF, highlighting the need for further study in this population.

Key points: · Pregnancy outcomes of patients with retroverted uterus have not been widely studied.. · Significantly more patients with a retroverted uterus conceived by in vitro fertilization.. · Patients with retroverted uterus were four times more likely to have first-trimester bleeding.. · Despite increased rates of vaginal bleeding, there was no increased rate of pregnancy loss..

妊娠早期子宫后移及相关妊娠结局。
目的:本研究旨在探讨颈透(NT)超声显示的逆行子宫是否与妊娠中期流产及其他不良妊娠结局有关。研究设计:这是一项回顾性队列研究,研究对象是2019年10月至2023年3月在一个学术医疗中心的NT超声记录的RV子宫患者。在产科超声成像程序中,使用查询“逆行”子宫位置来确定受试者。对于每个RV病例,选择两名前倾(AV)受试者进行比较。排除多胎妊娠、缪勒氏管异常或胎儿非整倍体的患者。通过图表回顾获得产妇人口统计、产科和新生儿结局。分类变量和连续变量分别采用Fisher精确检验和Mann-Whitney检验,p值结果:分析纳入249例患者- RV 83例和AV 166例。RV患者更容易被识别为高加索人(71.1比49.4%,p = 0.001),有私人保险(80.7比59.4%,p = 0.001),较低的体重指数(25.4±5.1比29.1±7.2,p = 0.018)。大多数RV受试者(98%)在妊娠中期消退。中期妊娠损失无差异(0比1.2%,p = 0.55)。在调整种族和体外受精后,RV受试者发生妊娠早期阴道出血的可能性是前者的4倍(16.9 vs. 4.2%,优势比= 4.1,p = 0.0056)。在不良结果方面没有观察到其他差异。结论:妊娠早期持续性RV子宫与妊娠早期阴道出血风险增加相关。然而,两组之间的妊娠率相似,为患者咨询提供了有价值的信息。通过体外受精(IVF)受孕的RV受试者明显增多,这突出了在这一人群中进一步研究的必要性。·子宫后倾患者的妊娠结局尚未得到广泛研究。·体外受精导致子宫逆行的患者明显增多。子宫内倾的患者妊娠早期出血的可能性是正常患者的4倍。·尽管阴道出血率增加,但流产率没有增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
American journal of perinatology
American journal of perinatology 医学-妇产科学
CiteScore
5.90
自引率
0.00%
发文量
302
审稿时长
4-8 weeks
期刊介绍: The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.
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