Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry.

IF 3.9 3区医学 Q2 CELL BIOLOGY

Aging-Us Pub Date : 2024-12-02 DOI:10.18632/aging.206161

Kazuto Aono, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Yukari Maeda, Hisaya Kato, Yoshiro Maezawa, Makoto Miyabayashi, Mai Ishikawa, Akiko Sekiguchi, Sei-Ichiro Motegi, Shinji Tsukamoto, Akira Taniguchi, Yukiko Shoda, Toru Yoshimura, Junji Kawashima, Kayo Yoshinaga, Hironori Nakagami, Yoichi Takami, Ken Sugimoto, Kunihiko Hashimoto, Naoki Okubo, Takashi Yoshida, Masato Ohara, Asako Kogure, Daisuke Suzuki, Masafumi Kuzuya, Kazuhisa Watanabe, Minoru Takemoto, Junko Oshima, Koutaro Yokote

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Abstract

Background and aim: Werner syndrome (WS) is an autosomal recessive, adult-onset, progeroid syndrome caused by WRN mutations. As refractory skin ulcers significantly affect the quality of life of patients with WS, this study identified ulcer risk factors and assessed prevention methods.

Methods: We analyzed the data of 51 patients with WS enrolled in the Japanese Werner Syndrome Registry between 2016 and 2022. A cross-sectional analysis was performed to determine the association with skin ulcers at baseline. Statistical analyses were conducted, including Welch's and Pearson's chi-square tests. Age was adjusted using a logistic regression model.

Results: The mean patient age was 48.8±7.6 years, and 66.7% of patients presented with skin ulcers. Univariate analysis showed that patients with skin ulcers were older than those without ulcers. Systolic blood pressure (SBP) was higher in patients with skin ulcers. Patients without skin ulcers received metformin and pioglitazone treatment significantly more often than those with ulcers. Logistic regression analysis adjusted for age showed that higher SBP remained a significant risk factor for skin ulcers. Patients administered pioglitazone had lower ulcer morbidity.

Conclusions: Age and SBP are risk factors for skin ulcers in patients with WS. Moreover, pioglitazone treatment may prevent skin ulcers.

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吡格列酮治疗的维尔纳综合征患者皮肤溃疡发生率较低：来自日本维尔纳综合征登记处的研究结果。

背景与目的：Werner综合征（WS）是由WRN突变引起的常染色体隐性、成人发病的类早衰综合征。由于难治性皮肤溃疡显著影响WS患者的生活质量，本研究确定了溃疡的危险因素并评估了预防方法。方法：我们分析了2016年至2022年在日本Werner综合征登记处登记的51例WS患者的数据。进行横断面分析以确定基线时与皮肤溃疡的关系。进行统计学分析，包括Welch’s和Pearson’s卡方检验。采用logistic回归模型调整年龄。结果：患者平均年龄为48.8±7.6岁，66.7%的患者出现皮肤溃疡。单因素分析显示，有皮肤溃疡的患者比没有皮肤溃疡的患者年龄大。皮肤溃疡患者的收缩压（SBP）较高。没有皮肤溃疡的患者接受二甲双胍和吡格列酮治疗的频率明显高于有溃疡的患者。经年龄调整后的Logistic回归分析显示，较高的收缩压仍然是皮肤溃疡的重要危险因素。服用吡格列酮的患者溃疡发病率较低。结论：年龄和收缩压是WS患者皮肤溃疡的危险因素。此外，吡格列酮治疗可以预防皮肤溃疡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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