Dosimetric comparison of Acuros^TM BV and AAPM TG-43 formalism for interstitial iridium-192 high-dose-rate brachytherapy.

IF 1.1 4区医学 Q4 ONCOLOGY

Journal of Contemporary Brachytherapy Pub Date : 2024-06-01 Epub Date: 2024-06-28 DOI:10.5114/jcb.2024.140893

Yiannis Roussakis, Georgios Antorkas, Leonidas Georgiou, Iosif Strouthos, Efstratios Karagiannis, Constantinos Zamboglou, Konstantinos Ferentinos, Nikolaos Zamboglou, Georgios Anagnostopoulos

{"title":"Dosimetric comparison of AcurosTM BV and AAPM TG-43 formalism for interstitial iridium-192 high-dose-rate brachytherapy.","authors":"Yiannis Roussakis, Georgios Antorkas, Leonidas Georgiou, Iosif Strouthos, Efstratios Karagiannis, Constantinos Zamboglou, Konstantinos Ferentinos, Nikolaos Zamboglou, Georgios Anagnostopoulos","doi":"10.5114/jcb.2024.140893","DOIUrl":null,"url":null,"abstract":"Purpose: The aim of this study was a retrospective dosimetric comparison of iridium-192 (192Ir) high-dose-rate (HDR) interstitial brachytherapy plans using model-based dose calculation algorithm (MBDCA) following TG-186 recommendations and TG-43 dosimetry protocol for breast, head-and-neck, and lung patient cohorts, with various treatment concepts and prescriptions.Material and methods: In this study, 59 interstitial 192Ir HDR brachytherapy cases treated in our center (22 breast, 22 head and neck, and 15 lung) were retrospectively selected and re-calculated with TG-43 dosimetry protocol as well as with AcurosTM BV dose calculation algorithm, with dose to medium option based on computed tomography images. Treatment planning dose volume parameter differences were determined and their significance was assessed.Results: For the breast planning target volume (PTV), TG-43 formalism calculated higher D90%, V95%, V100%, and V150% values than AcurosTM BV, ranging from 2.2% to 5.4% (mean differences), as it did for the head and neck cases, ranging from 2.5% to 4.7% and for the interstitial lung cases, ranging from 2.2% to 4.4%, showing statistical significance (p < 0.001). For the skin D0.1cm3, D0.2cm3, and D1cm3, the values were overestimated by TG-43, with a mean absolute differences of 1.4, 1.8, and 2.0 Gy, respectively for the breast, and 1.0 Gy for all DVH statistics for the head and neck cases compared with AcurosTM BV (p < 0.001). Ipsilateral lung V5Gy was also higher in TG-43-calculated plans, with a mean difference of 1.0% and 1.1% in the breast and lung implants, respectively. For the chest wall TG-43, the respective overestimation in D0.1cm3 and D1cm3 was 0.8 and 0.8 Gy for the breast, and 0.4 and 0.3 Gy for the interstitial lung cases, respectively.Conclusions: The TG-43 algorithm significantly overestimates the dose to PTVs and surrounding organs at risk (OARs) for breast, head and neck, and lung interstitial implants. TG-43 overestimation is in accordance with previous findings for breast and head and neck. To our knowledge, this is also exhibited for AcurosTM BV for the first time in interstitial lung HDR brachytherapy.","PeriodicalId":51305,"journal":{"name":"Journal of Contemporary Brachytherapy","volume":"16 3","pages":"211-218"},"PeriodicalIF":1.1000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609868/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Contemporary Brachytherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/jcb.2024.140893","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/28 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The aim of this study was a retrospective dosimetric comparison of iridium-192 (¹⁹²Ir) high-dose-rate (HDR) interstitial brachytherapy plans using model-based dose calculation algorithm (MBDCA) following TG-186 recommendations and TG-43 dosimetry protocol for breast, head-and-neck, and lung patient cohorts, with various treatment concepts and prescriptions.

Material and methods: In this study, 59 interstitial ¹⁹²Ir HDR brachytherapy cases treated in our center (22 breast, 22 head and neck, and 15 lung) were retrospectively selected and re-calculated with TG-43 dosimetry protocol as well as with Acuros^TM BV dose calculation algorithm, with dose to medium option based on computed tomography images. Treatment planning dose volume parameter differences were determined and their significance was assessed.

Results: For the breast planning target volume (PTV), TG-43 formalism calculated higher D_90%, V_95%, V_100%, and V_150% values than Acuros^TM BV, ranging from 2.2% to 5.4% (mean differences), as it did for the head and neck cases, ranging from 2.5% to 4.7% and for the interstitial lung cases, ranging from 2.2% to 4.4%, showing statistical significance (p < 0.001). For the skin D_0.1cm3, D_0.2cm3, and D_1cm3, the values were overestimated by TG-43, with a mean absolute differences of 1.4, 1.8, and 2.0 Gy, respectively for the breast, and 1.0 Gy for all DVH statistics for the head and neck cases compared with Acuros^TM BV (p < 0.001). Ipsilateral lung V_5Gy was also higher in TG-43-calculated plans, with a mean difference of 1.0% and 1.1% in the breast and lung implants, respectively. For the chest wall TG-43, the respective overestimation in D_0.1cm3 and D_1cm3 was 0.8 and 0.8 Gy for the breast, and 0.4 and 0.3 Gy for the interstitial lung cases, respectively.

Conclusions: The TG-43 algorithm significantly overestimates the dose to PTVs and surrounding organs at risk (OARs) for breast, head and neck, and lung interstitial implants. TG-43 overestimation is in accordance with previous findings for breast and head and neck. To our knowledge, this is also exhibited for Acuros^TM BV for the first time in interstitial lung HDR brachytherapy.

查看原文本刊更多论文

AcurosTM BV和AAPM TG-43形式在间质性铱-192高剂量率近距离治疗中的剂量学比较。

目的：本研究的目的是采用基于模型的剂量计算算法（MBDCA），根据TG-186推荐和TG-43剂量测定方案，对乳房、头颈部和肺部患者队列进行高剂量率（192Ir）间质性近距离放射治疗方案的回顾性剂量学比较，并采用不同的治疗理念和处方。材料与方法：本研究回顾性选择本中心收治的59例间质性192Ir HDR近距离放射治疗病例（乳房22例，头颈部22例，肺部15例），采用TG-43剂量测定方案和AcurosTM BV剂量计算算法重新计算，根据计算机断层图像选择剂量至中等。确定治疗计划、剂量、体积参数差异并评估其显著性。结果：TG-43公式计算的乳腺计划靶体积（PTV）的D90%、V95%、V100%、V150%值高于AcurosTM BV，分别为2.2% ~ 5.4%（平均差异），头颈部病例为2.5% ~ 4.7%，肺间质病例为2.2% ~ 4.4%，差异均有统计学意义（p < 0.001）。对于皮肤D0.1cm3, D0.2cm3和D1cm3， TG-43高估了该值，乳房的平均绝对差值分别为1.4,1.8和2.0 Gy，头颈部病例的所有DVH统计值与AcurosTM BV相比为1.0 Gy （p < 0.001）。tg -43计算方案的同侧肺V5Gy也较高，乳房和肺部植入物的平均差异分别为1.0%和1.1%。胸壁TG-43在乳腺D0.1cm3和D1cm3分别高估了0.8 Gy和0.8 Gy，肺间质组分别高估了0.4 Gy和0.3 Gy。结论：TG-43算法明显高估了乳房、头颈部和肺间质植入物对pvtv和周围危险器官（OARs）的剂量。TG-43的高估与先前对乳房和头颈部的研究结果一致。据我们所知，在肺间质性HDR近距离放射治疗中，AcurosTM BV也首次表现出这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Contemporary Brachytherapy ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

2.40

自引率

14.30%

发文量

审稿时长

16 weeks

期刊介绍： The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.