The Impact of Sleep Disorders on Glymphatic Function in Parkinson's Disease Using Diffusion Tensor MRI.

IF 3.8 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Academic Radiology Pub Date : 2024-12-02 DOI:10.1016/j.acra.2024.11.030

Yuting Li, Teng Zhang, Chao Wang, Leiyu Geng, Tingting Liu, Tong Lu, Shenghong Ju

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引用次数: 0

Abstract

Rationale and objectives: To investigate the impact of sleep disorders on glymphatic system in Parkinson's disease (PD) using a non-invasive imaging technique called diffusion tensor image analysis along perivascular space (DTI-ALPS).

Materials and methods: A total of 114 PD patients and 54 healthy controls (HCs) underwent sleep questionnaires and MRI examinations as part of data collection from the Parkinson's Progression Markers Initiative cohort. An automated pipeline was proposed for ALPS calculation to reduce biases from manually region delineation. ALPS indices were compared between PD and HCs, as well as between PD with and without sleep disorders. Correlation was assessed between ALPS index and clinical characteristics. Furthermore, a 2-year follow-up analysis was performed to explore longitudinal impact of sleep disorders on glymphatic function.

Results: PD patients showed significantly decreased ALPS indices compared with HCs (P = 0.038). PD patients with sleep disorders showed slightly but not significantly decreased ALPS index compared with those with normal sleep (P = 0.058). However, PD patients who transitioned from normal sleep to sleep disorders showed significantly decreased ALPS index at follow-up compared to baseline (P = 0.047). In contrast, patients who maintained normal sleep showed no significant difference in ALPS index between follow-up and baseline (P = 0.934). In addition, PD patients who transitioned from normal sleep to sleep disorders showed significantly increased ΔMDS-UPDRS Part I score (P = 0.004), ΔMDS-UPDRS total score (P = 0.040) and ΔSCOPA-AUT (P = 0.048) compared with PD who remained normal sleep.

Conclusion: Sleep disorders accelerate dysfunction of glymphatic system as indicated by ALPS index in PD patients, which may be associated with symptom progression in follow-up analysis. Therefore, more attention should be devoted to prevent sleep disorders in early PD.

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来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.