Dosimetric evaluation and Monte Carlo simulation of a new proposed surface brachytherapy mould.

IF 1.1 4区 医学 Q4 ONCOLOGY
Journal of Contemporary Brachytherapy Pub Date : 2024-08-01 Epub Date: 2024-09-16 DOI:10.5114/jcb.2024.143609
Fatemeh Salamat, Zahra Siavashpour, Mahdi Sadeghi, Ramin Jaberi, Somayeh Gholami
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引用次数: 0

Abstract

Purpose: The aim of this study was to develop a new in-house low-cost surface mould, and to evaluate its performance and dosimetric properties for high-dose-rate (HDR) cobalt-60 (60Co) brachytherapy.

Material and methods: A water-equivalent surface mould was developed using medical silicone. Mould performance and dosimetry characteristics were evaluated with Monte Carlo N-particle (MCNP2.6) simulation, Gafchromic™ EBT3 film measurements, and treatment planning system (TPS) output. Three sample moulds with different thicknesses (i.e., 0.5 cm, 1 cm, and 1.5 cm) were constructed, and a phantom study was performed. Treatment plans prescribing 3 Gy to 0.5 cm under pseudo-skin were designed, and film dosimetry was completed. TPS dose distributions were compared using Monte Carlo (MC) simulation and film dosimetry.

Results: Good consistency was observed between TPS results and film dosimetry at the prescribed depth of 0.5 cm, with mean differences of 0.70%, 0.40%, and 0.19% for mould thicknesses of 0.5 cm, 1 cm, and 1.5 cm, respectively. However, higher discrepancies were found at the phantom surface with 1.00%, 0.80%, and 0.56% dose differences for the considered mould thicknesses, respectively. These increased differences could be due to a higher dose gradient at the phantom surface, and a greater impact of uncertainties on the obtained results in this part. Moreover, mean differences between the results obtained from MC simulations and output of TPS at the prescribed depth of 0.5 cm were 0.73%, 0.60%, and 0.08% for mold thicknesses of 0.5 cm, 1 cm, and 1.5 cm, respectively. Higher variations were observed between TPS and MC at the phantom surface with 1.30%, 0.70%, and 0.13% dose differences for the considered mould thicknesses, respectively.

Conclusions: The developed surface mould demonstrated water equivalence at 60Co energies, and was consistent with TPS calculations at routine treatment depths. Its effectiveness in non-melanoma skin cancer (NMSC) lesion treatment is highlighted. However, due to mould attenuation, TG-43-based TPS overestimated the dose delivered using this mould, especially at pseudo-skin surface, emphasizing the necessity for a model-based TPS algorithm.

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来源期刊
Journal of Contemporary Brachytherapy
Journal of Contemporary Brachytherapy ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
2.40
自引率
14.30%
发文量
54
审稿时长
16 weeks
期刊介绍: The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.
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