Molecular imaging along the heart-kidney axis.

IF 12.4 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.7150/thno.102552
Konrad Klimek, Daniel Groener, Xinyu Chen, Steven P Rowe, Thimoteus Speer, Takahiro Higuchi, Rudolf A Werner
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引用次数: 0

Abstract

Cardiorenal syndrome (CRS) involves bidirectional crosstalk between the failing heart and the kidneys. Depending on the primum movens (primary cardiac or renal injury), systems-based interactions in the secondary affected organ may include pro-fibrotic signaling, overzealous inflammation, impaired nerve integrity or overactivity of specific renal transporters mediating glucose absorption. Those pathophysiological pillars can be investigated by molecular imaging using SPECT or PET agents. Targeted whole-body molecular imaging may allow for a) systems-based analysis along the heart-kidney axis, b) may provide prognostic information on longitudinal organ-based functional decline or c) may be used for guidance of reparative intervention based on peak activation identified on PET (paradigm of cardiorenal theranostics). We will discuss the current state of translational molecular imaging for CRS, along with future clinical aspects in the field.

沿心肾轴的分子成像。
心肾综合征(CRS)涉及衰竭的心脏和肾脏之间的双向串扰。根据原发运动(原发性心脏或肾脏损伤),继发受累器官中基于系统的相互作用可能包括促纤维化信号、过度炎症、神经完整性受损或介导葡萄糖吸收的特异性肾转运蛋白过度活跃。这些病理生理支柱可以通过SPECT或PET试剂的分子成像进行研究。有针对性的全身分子成像可以允许a)沿着心脏-肾脏轴进行基于系统的分析,b)可以提供纵向器官功能衰退的预后信息,或者c)可以用于指导基于PET识别的峰值激活的修复干预(心肾治疗的范式)。我们将讨论CRS转化分子成像的现状,以及该领域未来的临床方面。
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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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