SR3677 IS HEPATOPROTECTIVE IN MURINE LIVER ISCHEMIA/REPERFUSION INJURY: POTENTIAL ROLE OF BNIP3L/NIX (BCL2/ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 3-LIKE).

IF 2.7 3区医学 Q2 CRITICAL CARE MEDICINE

SHOCK Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI:10.1097/SHK.0000000000002527

Avinash Naraiah Mukkala, Vida Maksimoska, Emma Noble, Menachem Ailenberg, Raluca Petrut, Rachel Goldfarb, Andras Kapus, Katalin Szaszi, Ori David Rotstein

引用次数: 0

Abstract

Abstract: SR3677, a highly selective rho-associated protein kinase 2 inhibitor, administered prior to liver ischemia/reperfusion injury, induced hepatoprotection in both wild-type and Parkin2-/- mice. Experiments in hepatocytes identified BNIP3L/NIX, as a potential mediator of the hepatoprotective effects of SR3677.

查看原文本刊更多论文

SR3677在小鼠肝脏缺血/再灌注损伤中具有肝保护作用：BCL2/腺病毒E1B 19kda蛋白相互作用蛋白3样蛋白（BNIP3L/NIX）的潜在作用

SR3677是一种高选择性rho相关蛋白激酶2抑制剂，在肝脏缺血/再灌注损伤前给药，对野生型和Parkin2-/-小鼠均有肝保护作用。肝细胞实验发现BNIP3L/NIX是SR3677肝保护作用的潜在介质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

SHOCK 医学-外科

CiteScore

6.20

自引率

3.20%

发文量

199

审稿时长

1 months

期刊介绍： SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches includes studies of novel therapeutic approaches, such as immunomodulation, gene therapy, nutrition, and others. The mission of the Journal is to foster and promote multidisciplinary studies, both experimental and clinical in nature, that critically examine the etiology, mechanisms and novel therapeutics of shock-related pathophysiological conditions. Its purpose is to excel as a vehicle for timely publication in the areas of basic and clinical studies of shock, trauma, sepsis, inflammation, ischemia, and related pathobiological states, with particular emphasis on the biologic mechanisms that determine the response to such injury. Making such information available will ultimately facilitate improved care of the traumatized or septic individual.