Bovine leukemia virus (BLV) and risk of breast cancer; a systematic review and meta-analysis.

IF 2.7 3区医学 Q3 VIROLOGY

Retrovirology Pub Date : 2024-12-03 DOI:10.1186/s12977-024-00653-y

Fateme Saeedi-Moghaddam, Mahdi Mohammaditabar, Sayed-Hamidreza Mozhgani

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引用次数: 0

Abstract

Background: The role of viruses in the development of breast cancer has been a subject of debate and extensive research over the past few decades. Several studies have examined the association between Bovine leukemia virus (BLV) infection and the risk of developing breast cancer; however, their findings have yielded inconsistent results. To address this uncertainty, the purpose of the present study was to conduct a systematic review and meta-analysis to determine any potential association between BLV and breast cancer.

Methods: The literature search was performed by finding related articles from PubMed, Web of Science, Scopus, EMBASE, and ScienceDirect databases. Statistical analysis was conducted using the meta package in R Studio and Review Manager 5.1. The I² test was used to assess between-study heterogeneity. The Mantel-Haenszel method calculated the pooled odds ratio and its 95% confidence interval. Studies were divided into subgroups for comparison.

Results: The literature search identified a total of 17 studies that were deemed suitable for inclusion in the systematic review. Out of these 17 studies, 12 were used in the subsequent meta-analysis. Combining the data from these eligible studies, we calculated the pooled multi-factor adjusted odds ratio (OR) and a 95% confidence interval (CI). Considering the heterogeneity observed across the studies, the result obtained using the fixed effects model was 2.12 (1.77, 2.54). However, upon removing the six studies that contributed significantly to the heterogeneity, the pooled OR with a 95% CI was recalculated to be 3.92 (2.98, 5.16).

Conclusion: The result of this study suggests that BLV infection is statistically associated with Breast cancer.

查看原文本刊更多论文

牛白血病病毒（BLV）与乳腺癌风险系统回顾和荟萃分析。

背景：在过去的几十年里，病毒在乳腺癌发展中的作用一直是争论和广泛研究的主题。几项研究调查了牛白血病病毒（BLV）感染与患乳腺癌风险之间的关系；然而，他们的发现产生了不一致的结果。为了解决这一不确定性，本研究的目的是进行系统回顾和荟萃分析，以确定BLV和乳腺癌之间的任何潜在关联。方法：在PubMed、Web of Science、Scopus、EMBASE、ScienceDirect等数据库中检索相关文献。使用R Studio和Review Manager 5.1中的meta包进行统计分析。I2检验用于评估研究间异质性。Mantel-Haenszel方法计算了合并优势比及其95%置信区间。研究被分成亚组进行比较。结果：文献检索共确定了17项研究，认为适合纳入系统评价。在这17项研究中，有12项用于随后的荟萃分析。结合这些符合条件的研究的数据，我们计算了合并的多因素校正优势比（OR）和95%置信区间（CI）。考虑到各研究的异质性，采用固定效应模型得到的结果为2.12（1.77,2.54）。然而，在剔除6项对异质性有显著贡献的研究后，重新计算95% CI的合并OR为3.92（2.98,5.16）。结论：本研究结果提示BLV感染与乳腺癌有统计学相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retrovirology 医学-病毒学

CiteScore

5.80

自引率

3.00%

发文量

审稿时长

>0 weeks

期刊介绍： Retrovirology is an open access, online journal that publishes stringently peer-reviewed, high-impact articles on host-pathogen interactions, fundamental mechanisms of replication, immune defenses, animal models, and clinical science relating to retroviruses. Retroviruses are pleiotropically found in animals. Well-described examples include avian, murine and primate retroviruses. Two human retroviruses are especially important pathogens. These are the human immunodeficiency virus, HIV, and the human T-cell leukemia virus, HTLV. HIV causes AIDS while HTLV-1 is the etiological agent for adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. Retrovirology aims to cover comprehensively all aspects of human and animal retrovirus research.