Smartphone-Enabled Point-of-Care Testing for Prehospital Stroke Diagnosis.

IF 2.1 3区医学 Q2 EMERGENCY MEDICINE

Prehospital Emergency Care Pub Date : 2024-12-12 DOI:10.1080/10903127.2024.2437657

Paloma Menéndez-Valladares, Rosa M Delgado, David Núñez-Jurado, Lluis Sempere-Bordes, Anna Penalba, Leire Azurmendi, Claudio Parolo, Ana Barragán, Juan Antonio Cabezas, Carmen de Jesús Gil, José Moreno, Rafael Canto Neguillo, Roberto Valverde de Moyano, José Luis García Garmendia, Mercedes García Murillo, Ismael Muñoz Martínez, Antonia Romero Hidalgo, Francisco Aranda Aguilar, Soledad Pérez Sánchez, Jean-Charles Sánchez, Joan Montaner

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引用次数: 0

Abstract

Objectives: The objective of this study was to evaluate the feasibility of point-of-care testing (POCT) devices for N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement in prehospital settings, with the aim of improving the speed and accuracy of stroke diagnosis, thereby facilitating quicker and more effective patient care.

Methods: Prehospital blood samples were collected from suspected stroke patients, and NT-proBNP levels were measured using a POCT device in ambulances and hospitals. Results from the NT-proBNP POCT and smartphone images were analyzed. Plasma samples underwent Elecsys proBNP II immunoassay after storage at -80ºC.

Results: A total of 121 suspected stroke patients were included in the study. The correlation between POCT measured by the POCT and immunoassay for NT-proBNP was strong (R = 0.926). Smartphone images also strongly correlated with POCT values at 10 min (R²=0.9716) and 15 min (R²=0.9405). Stability analysis of samples showed consistent NT-proBNP results and a high correlation (R = 0.907) was observed between plasma and whole blood samples for NT-proBNP POCT.

Conclusions: This study highlights the potential of NT-proBNP POCT devices in ambulances to expedite stroke diagnosis and management within 10 min. Smartphone integration further enhances efficiency, adding advancement in prehospital stroke management.

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基于智能手机的院前卒中诊断即时检测。

目的：本研究的目的是评估院前检测n端前b型利钠肽（NT-proBNP） POCT设备的可行性，旨在提高脑卒中诊断的速度和准确性，从而促进更快、更有效的患者护理。方法：采集疑似脑卒中患者院前血液样本，在救护车和医院使用POCT装置检测NT-proBNP水平。分析NT-proBNP POCT和智能手机图像的结果。血浆样品在-80°C保存后进行Elecsys®pro BNP II免疫测定。结果：共纳入121例脑卒中疑似患者。POCT测定的POCT与NT-proBNP免疫测定的相关性较强（R = 0.926）。智能手机图像与10分钟和15分钟POCT值也有很强的相关性（R2=0.9716）。样品稳定性分析显示NT-proBNP结果一致，血浆和全血样品NT-proBNP POCT呈高相关性（R = 0.907）。结论：本研究强调了NT-proBNP POCT设备在救护车上10分钟内加快脑卒中诊断和管理的潜力。智能手机集成进一步提高了效率，增加了院前卒中管理的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prehospital Emergency Care 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.30

自引率

12.50%

发文量

137

审稿时长

1 months

期刊介绍： Prehospital Emergency Care publishes peer-reviewed information relevant to the practice, educational advancement, and investigation of prehospital emergency care, including the following types of articles: Special Contributions - Original Articles - Education and Practice - Preliminary Reports - Case Conferences - Position Papers - Collective Reviews - Editorials - Letters to the Editor - Media Reviews.