Hopkins Syndrome: An Uncommon Cause of Weakness in Intensive Care Unit.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Pediatric neurology Pub Date : 2024-11-14 DOI:10.1016/j.pediatrneurol.2024.11.006

Trajano Aguiar Pires Gonçalves, Maria Clara Zanon Zotin, Carolina Lavigne Moreira, Rodrigo Siqueira Soares Frezatti, Antonio Carlos Santos, Wilson Marques Junior, Pedro José Tomaselli

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引用次数: 0

Abstract

Background: Hopkins syndrome is a rare polio-like syndrome, with an incompletely understood pathophysiology, that affects children after asthma crisis.

Methods: A 10-year-old girl was admitted to the intensive care unit following a severe asthma attack, requiring mechanical ventilation for a period of five days. After regaining consciousness, the patient exhibited development of asymmetric flaccid paraparesis. Neuroaxis magnetic resonance imaging revealed contrast enhancement in the anterior lumbar roots, with the enhancement originating at the T11 level and extending downward on axial series. Nerve conduction study revealed the absence of compound muscle action potentials in the tibialis and peroneal nerves on the left, with preserved sensory nerve action potentials.

Results: Based on the patient's clinical phenotype, which was most consistent with a polio-like syndrome arising acutely following an asthmatic crisis, the diagnosis of Hopkins syndrome was established.

Conclusion: Hopkins syndrome is a rare polio-like syndrome that is probably underdiagnosed and has a poor motor prognosis.

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.