Guy Young, Riitta Lassila, Jane Mason, Saskia Prasca
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引用次数: 0
Abstract
Recently, the ISTH Hemophilia Guidelines were published in this journal. The authors of these guidelines should be commended for a Herculean task that took years to complete, and while this is no doubt a welcome addition to the literature, it does leave many questions for the clinician. Primarily this is due to as 11 of the 13 recommendations being conditional essentially meaning "that clinicians and patients need to consider individual preferences as well as the specific circumstances in which the decision is being made for implementation of the recommendation." So, in essence, most of the recommendations leave it up to the clinician to decide whether to use them or not. In our view, most clinicians are seeking more concrete recommendations when they seek out a guidelines paper. Unfortunately, hemophilia being a rare disease and the ISTH Guidelines relying upon the GRADE methodology resulted in so many conditional recommendations. We endeavored to "deconstruct" the ISTH recommendations and offer clinicians a more concrete path forward based in part on the guidelines but supplemented with more recent literature and our own extensive experience and perspective managing hemophilia patients of all ages from 4 continents.
期刊介绍:
The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community.
Types of Publications:
The journal publishes a variety of content, including:
Original research reports
State-of-the-art reviews
Brief reports
Case reports
Invited commentaries on publications in the Journal
Forum articles
Correspondence
Announcements
Scope of Contributions:
Editors invite contributions from both fundamental and clinical domains. These include:
Basic manuscripts on blood coagulation and fibrinolysis
Studies on proteins and reactions related to thrombosis and haemostasis
Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms
Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases
Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.