Correction to Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life

Abstract

Krzyzanski W, Stockard B, Gaedigk A, et al. Developmental pharmacokinetics of indomethacin in preterm neonates: severely decreased drug clearance in the first week of life. CPT Pharmacometrics Syst Pharmacol. 2023;12:110–121. doi:10.1002/psp4.12881

In the published version of the above article, the equation reported to convert dried blood spot (DBS) indomethacin concentrations to plasma concentrations is incorrect. Rather than “plasma[IND] = DBS[IND]/(1 – hematocrit) * 1.608,” the equation should be “C(plasma) = 1.837(C(DBS)/(1 – Hct/100)) – 236.6.” There is also an inaccurate statement in the Bioanalytical methods section: “A correction factor (1.608, mean of the ratio of plasma:DBS concentrations) was used to calculate the theoretical plasma concentrations from the hematocrit-corrected DBS concentration,” which does not align with the data analysis that was performed.

This author error in reporting does not affect the results or conclusions of the paper as the correct equation (more accurate and appropriate) was used to convert DBS to plasma concentrations for data analysis, and the wrong equation was reported in the manuscript.

We apologize for this error.