An Association between Bilirubin and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus: An Effect Modification by Nrf2 Polymorphisms.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM

Current diabetes reviews Pub Date : 2024-11-29 DOI:10.2174/0115733998327164240923070313

Qiwei Fan, Shanshan Feng, Jianrong Chen, Yan Zhang, Jixiong Xu, Jiancheng Wang

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引用次数: 0

Abstract

Background: Diabetic retinopathy (DR) is a persistent microvascular complication associated with diabetes, and it constitutes a significant cause of visual impairment and blindness.

Aims: This study aimed to assess the correlation between serum bilirubin levels and the prevalence of DR in patients diagnosed with type 2 diabetes mellitus (T2DM). Additionally, we sought to establish whether the polymorphisms of Nuclear Factor E2-Related Factor 2 (Nrf2) might modify this relationship.

Methods: A cross-sectional study was undertaken in Jiangxi, China, from May, 2012 to December, 2014. Serum bilirubin levels were assessed in 558 subjects, and the correlation between bilirubin and DR was analyzed using generalized linear models with a logit link. The study utilized odds ratios (OR) and 95% confidence intervals (CI) to evaluate the relationship, both with and without the consideration of clinical risk factors.

Results: There was a significant inverse association between serum total bilirubin (TBiL) and the risk of DR (per 1-μmol/L increment; OR, 0.89; 95% CI: 0.84-0.94). Accordingly, when TBiL was categorized into tertiles, individuals in tertiles 2 and 3 exhibited significantly lower risks of DR compared to those in tertile 1. The OR for these tertiles was 0.54 (95% CI: 0.34-0.87) and 0.31 (95% CI: 0.19-0.52), respectively. Moreover, a stronger inverse relationship between TBiL and DR was observed in individuals carrying the CC and AC genotypes compared to those with the AA genotype. The OR for individuals with the CC/AC genotype was 0.87 (95% CI: 0.82, 0.92), while that for the AA genotype was 1.17 (95% CI: 0.95, 1.45). This difference was statistically significant (p for interaction = 0.001).

Conclusion: There was a significant inverse association between bilirubin and DR in participants with CC or AC genotype. However, this inverse association was not seen in AA genotype participants.

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2型糖尿病患者胆红素与糖尿病视网膜病变的关系：Nrf2多态性的影响

背景：糖尿病视网膜病变（DR）是一种与糖尿病相关的持续性微血管并发症，是导致视力损害和失明的重要原因。目的：本研究旨在评估2型糖尿病（T2DM）患者血清胆红素水平与DR患病率之间的相关性。此外，我们试图确定核因子e2相关因子2 （Nrf2）的多态性是否可能改变这种关系。方法：于2012年5月至2014年12月在中国江西省进行横断面研究。对558名受试者的血清胆红素水平进行评估，并使用具有logit链接的广义线性模型分析胆红素与DR之间的相关性。该研究利用优势比（OR）和95%置信区间（CI）来评估两者之间的关系，无论是否考虑临床危险因素。结果：血清总胆红素（TBiL）与DR发生风险呈显著负相关(每增加1 μmol/L；或者,0.89;95% ci: 0.84-0.94)。因此，当将TBiL分类为三类时，三类2和三类个体的DR风险明显低于三类1。这些三分位数的OR分别为0.54 （95% CI: 0.34-0.87）和0.31 （95% CI: 0.19-0.52）。此外，在携带CC和AC基因型的个体中，与携带AA基因型的个体相比，TBiL和DR之间存在更强的负相关。CC/AC基因型个体的OR为0.87 (95% CI: 0.82, 0.92)， AA基因型个体的OR为1.17 （95% CI: 0.95, 1.45）。这一差异具有统计学意义（交互作用p = 0.001）。结论：CC或AC基因型患者胆红素与DR呈显著负相关。然而，在AA基因型参与者中未见这种负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current diabetes reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

6.30

自引率

0.00%

发文量

158

期刊介绍： Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.