Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review

IF 6.9 3区医学 Q1 CHEMISTRY, MEDICINAL

Archives of Pharmacal Research Pub Date : 2024-12-03 DOI:10.1007/s12272-024-01522-0

Sibhghatulla Shaikh, Khurshid Ahmad, Jeong Ho Lim, Syed Sayeed Ahmad, Eun Ju Lee, Inho Choi

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Abstract

The recent resurgence of traditional medicines, driven by a renewed interest in the medicinal use of plant extracts, has garnered significant scientific attention for their therapeutic efficacy in treating a wide range of diseases. Glycyrrhiza species, commonly known as licorice, are widely recognized both as herbal remedies and as natural sweeteners. Among these, Glycyrrhiza uralensis stands out for its exceptional therapeutic potential, particularly in enhancing muscle regeneration, slowing muscle aging, and promoting skeletal muscle myogenesis. This review explores the traditional uses and biological effects of G. uralensis, highlighting the biological significance of its bioactive constituents, such as saponins and flavonoids. The hepatoprotective, antibacterial, antioxidant, anticancer, antidiabetic, antiobesity, anti-inflammatory, skeletal muscle-enhancing and cardiovascular effects of G. uralensis are reviewed, along with its toxicity and safety profile. Additionally, we propose directions for future clinical and scientific investigations, advocating for using G. uralensis as a natural therapeutic agent. The primary aim of this review is to contribute to the incorporation of this ancient medicine into modern clinical practice.

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乌拉尔甘草及其活性化合物的生物学研究进展及其治疗潜力。

最近，由于对植物提取物的药用重新产生兴趣，传统药物重新兴起，并因其治疗多种疾病的疗效而引起了科学界的极大关注。甘草属植物，通常被称为甘草，被广泛认为是草药和天然甜味剂。其中，乌拉尔甘草因其特殊的治疗潜力而脱颖而出，特别是在增强肌肉再生、减缓肌肉衰老和促进骨骼肌肌肉生成方面。本文综述了乌拉尔草的传统用途和生物学效应，重点介绍了乌拉尔草的生物活性成分，如皂苷和黄酮类化合物的生物学意义。综述了乌拉尔草的保肝、抗菌、抗氧化、抗癌、降糖、抗肥胖、抗炎、增强骨骼肌和心血管作用，以及其毒性和安全性。此外，我们提出了未来临床和科学研究的方向，主张将乌拉尔草作为天然治疗剂使用。本综述的主要目的是有助于将这一古老医学纳入现代临床实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Pharmacal Research 医学-药学

CiteScore

13.40

自引率

9.00%

发文量

审稿时长

3.3 months

期刊介绍： Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.