Alkali Metal Amide-Catalyzed α-Deuteration of Sulfides

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-12-02 DOI:10.1021/acs.orglett.4c03654

Hui-Zhen Du, Bing-Tao Guan

引用次数: 0

Abstract

The catalytic α-deuteration of sulfides was developed under mild conditions by using alkali metal amides [KN(SiMe₃)₂ and CsN(SiMe₃)₂] as the catalyst. This approach successfully achieves a selective and efficient H/D exchange reaction of sulfides with D₂ without using transition metal catalysts. A series of deuterium-labeled thioanisoles and alkyl methyl sulfides were obtained in good to high levels of deuterium incorporation.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.