Oguzhan Inceli, Cemile Sonmez, Elif Ece İnceli, Hasan Onur Topçu, Mujde Can Ibanoglu, Yaprak Engin-Ustun
{"title":"Transplacental Transport Rates of Anti-pertussis Toxin-IgG and Anti-filamentous Hemagglutinin-IgG Antibodies in Newborns by Week of Birth.","authors":"Oguzhan Inceli, Cemile Sonmez, Elif Ece İnceli, Hasan Onur Topçu, Mujde Can Ibanoglu, Yaprak Engin-Ustun","doi":"10.1055/a-2457-2721","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong> The aim of this study is to investigate the lack of knowledge about the transplacental transport of antibodies in unvaccinated term and preterm infants and possible differences in antibody-mediated immunity in the fetus depending on maternal vaccination in their own infancy.</p><p><strong>Study design: </strong> The study was conducted as a prospective cross-sectional study between 2017 and 2018 and included a total of 334 participants. The study included 194 pregnant women with a preterm birth (before 37 weeks) and 140 pregnant women with a term birth. Both umbilical cord blood and maternal blood were used to measure serum levels of anti-pertussis toxin (PT) immunoglobulin (Ig) G and anti-filamentous hemagglutinin (FHA) IgG.</p><p><strong>Results: </strong> The results showed that anti-FHA IgG antibody levels in the cord blood of women who had delivered at term were significantly higher than those of preterm infants (<i>p</i> = 0.002). The placental transfer rate of anti-PT IgG was higher in women who delivered prematurely, but this difference was not statistically significant (<i>p</i> = 0.128). However, transfer rates for anti-FHA were significantly higher in women who had delivered prematurely (<i>p</i> = 0.001). In addition, transmission rates for both antibodies were found to be significantly lower in women who delivered before 32 weeks gestation than in women who delivered at term (<i>p</i> = 0.006, <i>p</i> < 0.001). Antibody transfer rates were found to be positively correlated with both gestational age and birth weight.</p><p><strong>Conclusion: </strong> In summary, although placental antibody transfer rates increased with gestational age, transfer rates and antibody levels were low in pregnant women, particularly in women who had given birth before 32 weeks gestation.</p><p><strong>Key points: </strong>· Transport. · Anti-PT IgG. · Anti-FHA IgG antibodies.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2457-2721","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: The aim of this study is to investigate the lack of knowledge about the transplacental transport of antibodies in unvaccinated term and preterm infants and possible differences in antibody-mediated immunity in the fetus depending on maternal vaccination in their own infancy.
Study design: The study was conducted as a prospective cross-sectional study between 2017 and 2018 and included a total of 334 participants. The study included 194 pregnant women with a preterm birth (before 37 weeks) and 140 pregnant women with a term birth. Both umbilical cord blood and maternal blood were used to measure serum levels of anti-pertussis toxin (PT) immunoglobulin (Ig) G and anti-filamentous hemagglutinin (FHA) IgG.
Results: The results showed that anti-FHA IgG antibody levels in the cord blood of women who had delivered at term were significantly higher than those of preterm infants (p = 0.002). The placental transfer rate of anti-PT IgG was higher in women who delivered prematurely, but this difference was not statistically significant (p = 0.128). However, transfer rates for anti-FHA were significantly higher in women who had delivered prematurely (p = 0.001). In addition, transmission rates for both antibodies were found to be significantly lower in women who delivered before 32 weeks gestation than in women who delivered at term (p = 0.006, p < 0.001). Antibody transfer rates were found to be positively correlated with both gestational age and birth weight.
Conclusion: In summary, although placental antibody transfer rates increased with gestational age, transfer rates and antibody levels were low in pregnant women, particularly in women who had given birth before 32 weeks gestation.
期刊介绍：
The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields.
The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field.
All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication.
The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
