Toxicokinetics of benzotriazole UV stabilizer UV-P in humans after single oral administration

IF 4.8 2区 医学 Q1 TOXICOLOGY
Corinna Fischer, Julia Hiller, Edgar Leibold, Thomas Göen
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引用次数: 0

Abstract

UV-P (2-(2H-Benzotriazol-2-yl)-p-cresol) is used as an ultraviolet (UV) light absorber in coating products, paints, adhesives, and sealants. Due to its widespread industrial and consumer uses, human exposure to UV-P is conceivable. In the study presented herein, initial data on its human in vivo metabolism were obtained for three study participants after single oral administration of 0.3 mg of UV-P/kg body weight. Urine and blood samples of two volunteers were collected up to 48 h after exposure. The third study participant donated urine and blood samples up to 72 h. Maximum levels of UV-P in blood of 184 ± 36 µg/l (85 ± 3% as conjugates) were reached 2.4 ± 1.2 h post-exposure. Maximum excretion rates of UV-P in urine of 2896 ± 884 µg/h (completely conjugated) were reached 3.5 ± 1.1 h post-exposure. 37.2 ± 5.4% of the orally administered dose of UV-P was recovered in urine within 48 h post-exposure. The present study provides insight into the complex absorption, distribution, metabolism, and elimination (ADME) processes of benzotriazole UV stabilizers (BUVS). The study also demonstrates differences in the ADME between sterically hindered BUVS, such as UV-327 and UV-328, and sterically unhindered BUVS, such as UV-P, in which the phenolic hydroxyl group is readily accessible for conjugation with glucuronic acid or sulfate.

单次口服苯并三唑紫外线稳定剂UV- p在人体内的毒性动力学。
UV- p (2-(2h -苯并三唑-2-基)-对甲酚)在涂料产品、油漆、粘合剂和密封剂中用作紫外线吸收剂。由于其广泛的工业和消费用途,人类暴露于UV-P是可以想象的。在本文提出的研究中,获得了3名研究参与者在单次口服0.3 mg UV-P/kg体重后的人体体内代谢的初步数据。两名志愿者在接触后48小时内收集尿液和血液样本。第三个研究参与者捐献尿液和血液样本长达72小时。暴露后2.4±1.2小时,血液中UV-P的最高水平达到184±36µg/l(85±3%为结合物)。暴露后3.5±1.1 h,尿液中UV-P的最大排泄率达到2896±884µg/h(完全偶联)。37.2±5.4%的口服剂量的UV-P在暴露后48 h内从尿液中回收。本研究揭示了苯并三唑类紫外线稳定剂(BUVS)的复杂吸收、分布、代谢和消除过程。该研究还证明了空间阻碍BUVS(如UV-327和UV-328)和空间无阻碍BUVS(如UV-P)之间ADME的差异,其中酚羟基很容易与葡萄糖醛酸或硫酸盐结合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Archives of Toxicology
Archives of Toxicology 医学-毒理学
CiteScore
11.60
自引率
4.90%
发文量
218
审稿时长
1.5 months
期刊介绍: Archives of Toxicology provides up-to-date information on the latest advances in toxicology. The journal places particular emphasis on studies relating to defined effects of chemicals and mechanisms of toxicity, including toxic activities at the molecular level, in humans and experimental animals. Coverage includes new insights into analysis and toxicokinetics and into forensic toxicology. Review articles of general interest to toxicologists are an additional important feature of the journal.
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