Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2024-11-30 DOI:10.1186/s12943-024-02183-9

Hua Wang, Tao Wang, Shuxiang Yan, Jinxin Tang, Yibo Zhang, Liming Wang, Haodong Xu, Chao Tu

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Abstract

In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in tumor initiation and progression, shaped by complex interactions between cancer cells and surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted by various cellular constituents within the TME, including immune cells, cancer-associated fibroblasts, and cancer cells themselves. These cytokines facilitate intricate communication networks that significantly influence tumor initiation, progression, metastasis, and immune suppression. Pyroptosis contributes to TME remodeling by promoting the release of pro-inflammatory cytokines and sustaining chronic inflammation, impacting processes such as immune escape and angiogenesis. However, challenges remain due to the complex interplay among cytokines, pyroptosis, and the TME, along with the dual effects of pyroptosis on cancer progression and therapy-related complications like cytokine release syndrome. Unraveling these complexities could facilitate strategies that balance inflammatory responses while minimizing tissue damage during therapy. This review delves into the complex crosstalk between cytokines, pyroptosis, and the TME, elucidating their contribution to tumor progression and metastasis. By synthesizing emerging therapeutic targets and innovative technologies concerning TME, this review aims to provide novel insights that could enhance treatment outcomes for cancer patients.

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肿瘤微环境中焦亡与细胞因子的串扰：从机制到临床意义

在癌症研究领域，肿瘤微环境（tumor microenvironment， TME）在肿瘤的发生和发展中起着至关重要的作用，它是由癌细胞和周围非癌细胞之间复杂的相互作用形成的。细胞因子是重要的免疫调节剂，由TME内的各种细胞成分分泌，包括免疫细胞、癌症相关成纤维细胞和癌细胞本身。这些细胞因子促进了复杂的通讯网络，显著影响肿瘤的发生、进展、转移和免疫抑制。焦亡通过促进促炎细胞因子的释放和维持慢性炎症，影响免疫逃逸和血管生成等过程，有助于TME重塑。然而，由于细胞因子、焦亡和TME之间复杂的相互作用，以及焦亡对癌症进展和细胞因子释放综合征等治疗相关并发症的双重影响，挑战仍然存在。解开这些复杂性可以促进平衡炎症反应的策略，同时最大限度地减少治疗过程中的组织损伤。这篇综述深入探讨了细胞因子、焦亡和TME之间的复杂串扰，阐明了它们对肿瘤进展和转移的贡献。通过对TME相关的新兴治疗靶点和创新技术的综合研究，本综述旨在为提高癌症患者的治疗效果提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.