Diabetes remission in newly diagnosed type 2 diabetes mellitus through short-term continuous subcutaneous insulin infusion intensive therapy combined with low-carbohydrate diet treatment

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-11-28 DOI:10.1111/jdi.14371

Xuemei Huang, Jiajin Jiang, Li Liu, Yuanyuan Lin, Feng Zhang, Xiaoshan Ling, Haitao Wei, Guangjing Huang, Jinqun Ye, Cen Huang, Jianli Huang, Wenfu Tao, Xinyu Zou

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Abstract

Aim/Introduction

To evaluate the therapeutic efficacy short-term continuous subcutaneous insulin infusion (CSII) intensive therapy combined with a low-carbohydrate diet (LCD) for diabetes remission in patients with newly diagnosed type 2 diabetes mellitus.

Materials and Methods

This study included patients newly diagnosed with type 2 diabetes mellitus, who were randomly divided into two groups: conventional (conventional CSII + traditional lifestyle guidance); and intensive (intensive CSII + LCD lifestyle guidance). CSII was used for blood glucose control, with continuous glucose monitoring (CGM) used to monitor blood glucose levels. The primary outcome measure was hemoglobin A1c (HbA1c) level; secondary outcomes included body weight, body mass index (BMI), waist circumference, glycemic control, and biochemical indices.

Results

The time in range (TIR) in the intensive treatment group was greater than that in the conventional treatment group (P < 0.05). There was no significant difference in the incidence of hypoglycemia between the two groups (P > 0.05). Compared with the conventional treatment group, diabetes remission rates were significantly greater in the intensive treatment group (P < 0.05). In the intensive treatment group, fasting plasma glucose (FPG), HbA1c, Homeostasis Model assessment of Insulin Resistance (HOMA-IR), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and changes in body weight, BMI, visceral fat area (VFA), and subcutaneous fat area (SFA) decreased significantly (P < 0.05). FPG, HOMA-IR, TG, LDL-c, and changes in body weight, BMI, waist circumference, and VFA were significantly correlated with HbA1c levels (P < 0.05).

Conclusions

The combination of intensive CSII and LCD lifestyle guidance had been improved the remission rate in patients with newly diagnosed type 2 diabetes mellitus.

Abstract Image

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通过短期持续皮下胰岛素输注强化治疗结合低碳水化合物饮食治疗新诊断的2型糖尿病的缓解。

目的/简介：评价短期持续皮下胰岛素输注（CSII）强化治疗联合低碳水化合物饮食（LCD）对新诊断的2型糖尿病患者糖尿病缓解的疗效。材料与方法：本研究纳入新诊断的2型糖尿病患者，随机分为常规组（常规CSII +传统生活方式指导）；强化（强化CSII + LCD生活方式指导）。CSII用于控制血糖，连续血糖监测（CGM）用于监测血糖水平。主要结局指标为血红蛋白A1c （HbA1c）水平；次要结局包括体重、身体质量指数（BMI）、腰围、血糖控制和生化指标。结果：强化治疗组的范围内时间（TIR）大于常规治疗组（p0.05）。与常规治疗组比较，强化治疗组糖尿病缓解率显著高于常规治疗组(P)。结论：强化CSII结合LCD生活方式指导可提高新诊断2型糖尿病患者的缓解率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).