CIDGMed: Causal Inference-Driven Medication Recommendation with Enhanced Dual-Granularity Learning

IF 7.2 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE
Shunpan Liang , Xiang Li , Shi Mu , Chen Li , Yu Lei , Yulei Hou , Tengfei Ma
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引用次数: 0

Abstract

Medication recommendation aims to integrate patients’ long-term health records to provide accurate and safe medication combinations for specific health states. Existing methods often fail to deeply explore the true causal relationships between diseases/procedures and medications, resulting in biased recommendations. Additionally, in medication representation learning, the relationships between information at different granularities of medications—coarse-grained (medication itself) and fine-grained (molecular level)—are not effectively integrated, leading to biases in representation learning. To address these limitations, we propose the Causal Inference-driven Dual-Granularity Medication Recommendation method (CIDGMed). Our approach leverages causal inference to uncover the relationships between diseases/procedures and medications, thereby enhancing the rationality and interpretability of recommendations. By integrating coarse-grained medication effects with fine-grained molecular structure information, CIDGMed provides a comprehensive representation of medications. Additionally, we employ a bias correction model during the prediction phase to further refine recommendations, ensuring both accuracy and safety. Through extensive experiments, CIDGMed significantly outperforms current state-of-the-art models across multiple metrics, achieving a 2.54% increase in accuracy, a 3.65% reduction in side effects, and a 39.42% improvement in time efficiency. Additionally, we demonstrate the rationale of CIDGMed through a case study.
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来源期刊
Knowledge-Based Systems
Knowledge-Based Systems 工程技术-计算机:人工智能
CiteScore
14.80
自引率
12.50%
发文量
1245
审稿时长
7.8 months
期刊介绍: Knowledge-Based Systems, an international and interdisciplinary journal in artificial intelligence, publishes original, innovative, and creative research results in the field. It focuses on knowledge-based and other artificial intelligence techniques-based systems. The journal aims to support human prediction and decision-making through data science and computation techniques, provide a balanced coverage of theory and practical study, and encourage the development and implementation of knowledge-based intelligence models, methods, systems, and software tools. Applications in business, government, education, engineering, and healthcare are emphasized.
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