Appendectomy, acute appendicitis, and gastrointestinal diseases: A Mendelian randomization study

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2024-11-23 DOI:10.1016/j.amjsurg.2024.116107

Yi Zhao , Xuecheng Bai , Yi Ding , Cheng Cui , Dongning Zheng , Benjian Gao , Yongfa Liu , Shuai Hu , Yaling Li , Xiaoli Yang , Bo Li

{"title":"Appendectomy, acute appendicitis, and gastrointestinal diseases: A Mendelian randomization study","authors":"Yi Zhao , Xuecheng Bai , Yi Ding , Cheng Cui , Dongning Zheng , Benjian Gao , Yongfa Liu , Shuai Hu , Yaling Li , Xiaoli Yang , Bo Li","doi":"10.1016/j.amjsurg.2024.116107","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Appendectomy is the standard treatment for acute appendicitis. However, the effects of appendectomy and acute appendicitis on gastrointestinal diseases are not fully understood.</div></div><div><h3>Methods</h3><div>Genetic variants associated with appendectomy and acute appendicitis at a genome-wide significance level (<em>P</em> < 5.0E−08) were selected as instrumental variables. Two-sample univariate and multivariate Mendelian randomization (MR) analyses were performed to examine the independent effects of appendectomy and acute appendicitis on related gastrointestinal diseases.</div></div><div><h3>Results</h3><div>Appendectomy was linked to an increased risk of colon cancer (odds ratio [OR], 1.54; 95 % confidence interval [CI], 1.15–2.07; <em>P</em> = 0.004; FDR-corrected <em>P</em> = 0.016) and a decreased risk of primary sclerosing cholangitis (OR, 0.57; 95 % CI, 0.38–0.84; <em>P</em> = 0.004; FDR-corrected <em>P</em> = 0.016). Acute appendicitis was associated with a higher risk of cholelithiasis (OR, 1.16; 95 % CI, 1.06–1.27; <em>P</em> = 0.002; FDR-corrected <em>P</em> = 0.016).</div></div><div><h3>Conclusion</h3><div>This study suggested that appendectomy and acute appendicitis might affect the risk of several gastrointestinal diseases in European populations.</div></div>","PeriodicalId":7771,"journal":{"name":"American journal of surgery","volume":"240 ","pages":"Article 116107"},"PeriodicalIF":2.7000,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002961024006597","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Appendectomy is the standard treatment for acute appendicitis. However, the effects of appendectomy and acute appendicitis on gastrointestinal diseases are not fully understood.

Methods

Genetic variants associated with appendectomy and acute appendicitis at a genome-wide significance level (P < 5.0E−08) were selected as instrumental variables. Two-sample univariate and multivariate Mendelian randomization (MR) analyses were performed to examine the independent effects of appendectomy and acute appendicitis on related gastrointestinal diseases.

Results

Appendectomy was linked to an increased risk of colon cancer (odds ratio [OR], 1.54; 95 % confidence interval [CI], 1.15–2.07; P = 0.004; FDR-corrected P = 0.016) and a decreased risk of primary sclerosing cholangitis (OR, 0.57; 95 % CI, 0.38–0.84; P = 0.004; FDR-corrected P = 0.016). Acute appendicitis was associated with a higher risk of cholelithiasis (OR, 1.16; 95 % CI, 1.06–1.27; P = 0.002; FDR-corrected P = 0.016).

Conclusion

This study suggested that appendectomy and acute appendicitis might affect the risk of several gastrointestinal diseases in European populations.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.