Appendectomy, acute appendicitis, and gastrointestinal diseases: A Mendelian randomization study

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2024-11-23 DOI:10.1016/j.amjsurg.2024.116107

Yi Zhao , Xuecheng Bai , Yi Ding , Cheng Cui , Dongning Zheng , Benjian Gao , Yongfa Liu , Shuai Hu , Yaling Li , Xiaoli Yang , Bo Li

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引用次数: 0

Abstract

Background

Appendectomy is the standard treatment for acute appendicitis. However, the effects of appendectomy and acute appendicitis on gastrointestinal diseases are not fully understood.

Methods

Genetic variants associated with appendectomy and acute appendicitis at a genome-wide significance level (P < 5.0E−08) were selected as instrumental variables. Two-sample univariate and multivariate Mendelian randomization (MR) analyses were performed to examine the independent effects of appendectomy and acute appendicitis on related gastrointestinal diseases.

Results

Appendectomy was linked to an increased risk of colon cancer (odds ratio [OR], 1.54; 95 % confidence interval [CI], 1.15–2.07; P = 0.004; FDR-corrected P = 0.016) and a decreased risk of primary sclerosing cholangitis (OR, 0.57; 95 % CI, 0.38–0.84; P = 0.004; FDR-corrected P = 0.016). Acute appendicitis was associated with a higher risk of cholelithiasis (OR, 1.16; 95 % CI, 1.06–1.27; P = 0.002; FDR-corrected P = 0.016).

Conclusion

This study suggested that appendectomy and acute appendicitis might affect the risk of several gastrointestinal diseases in European populations.

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阑尾切除术、急性阑尾炎和胃肠道疾病：一项孟德尔随机研究

背景阑尾切除术是急性阑尾炎的标准治疗方法。然而，阑尾切除术和急性阑尾炎对胃肠道疾病的影响尚不完全清楚。方法与阑尾切除术和急性阑尾炎相关的遗传变异具有全基因组显著性水平(P <；5.0E−08)作为工具变量。采用双样本单变量和多变量孟德尔随机化（MR）分析来检验阑尾切除术和急性阑尾炎对相关胃肠道疾病的独立影响。结果阑尾切除术与结肠癌风险增加相关(优势比[OR]， 1.54；95%置信区间[CI]， 1.15-2.07；p = 0.004；fdr校正P = 0.016)和原发性硬化性胆管炎的风险降低(OR, 0.57；95% ci, 0.38-0.84；p = 0.004；fdr校正P = 0.016)。急性阑尾炎与胆石症的高风险相关(OR, 1.16；95% ci, 1.06-1.27；p = 0.002；fdr校正P = 0.016)。结论本研究提示阑尾切除术和急性阑尾炎可能影响欧洲人群多种胃肠道疾病的发生风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.