Is there an association between inflammatory biomarkers and organ space surgical site infection after emergency laparotomy in massively transfused trauma patients?

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2024-11-19 DOI:10.1016/j.amjsurg.2024.116106

Stephanie Martinez Ugarte , Mokunfayo O. Fajemisin , Chelsea J. Guy-Frank , James M. Klugh , Xu Zhang , Erin E. Fox , Charles E. Wade , Kimberly A. Mankiewicz , Lillian S. Kao

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引用次数: 0

Abstract

Background

The relationship between inflammatory biomarkers (IB) and organ space surgical site infections (OS-SSIs) after emergency laparotomy (EL) is poorly understood.

Methods

Retrospective, single-center analysis of patients in the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial who underwent EL and survived 48 h after admission was performed. IB levels of IL-6, IL-8, G-CSF, MCP-1, neutrophil to lymphocyte ratio, and platelet to lymphocyte ratio were analyzed. IB and OS-SSIs association was evaluated using the Wilcoxon rank sum test.

Results

Of 74 eligible patients, 80 % were male, 69 % sustained blunt trauma, the injury severity score was 31 (24–41), and 22 % developed OS-SSIs. Levels of IL-6 (12, 24 h), IL-8 (2, 12, 24, 72 h), and MCP-1 (24 h) were higher in OS-SSI patients (P < 0.05).

Conclusions

IL-6, IL-8, and MCP-1 levels were associated with OS-SSIs in PROPPR patients who underwent EL. The IB may help to predict high-risk patients for OS-SSIs.

Abstract Image

查看原文本刊更多论文

在大量输血的创伤患者急诊剖腹手术后，炎症生物标志物与器官间隙手术部位感染之间是否存在关联？

背景炎性生物标志物（IB）与急诊剖腹手术（EL）后器官间隙手术部位感染（os - ssi）之间的关系尚不清楚。方法回顾性、单中心分析实用、随机最佳血小板和血浆比率（PROPPR）试验中接受EL治疗并在入院后48小时存活的患者。分析IB中IL-6、IL-8、G-CSF、MCP-1水平、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值。使用Wilcoxon秩和检验评估IB和os - ssi的相关性。结果74例患者中，80%为男性，69%为钝性创伤，损伤严重程度评分为31分（24-41分），22%为os - ssi。OS-SSI患者IL-6（12、24小时）、IL-8（2、12、24、72小时）和MCP-1（24小时）水平较高(P <；0.05)。结论il -6、IL-8和MCP-1水平与EL患者os - ssi相关。IB可能有助于预测os - ssi高危患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.