Structural development of curcumin: A natural product arsenal for diverse therapeutic targets- seizing opportunities through serendipity and rational design

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2024-11-23 DOI:10.1016/j.molstruc.2024.140815

Mahmood Ahmed , Sehar Basheer , Mohammed H. AL Mughram , Dure Najaf Iqbal , Shaista Qamar , Ahmad Saeed , Rida Batool , Mudassar Sanaullah , Hussain Raza , Riaz Hussain

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Abstract

Curcumin, a polyphenolic compound found in turmeric, has demonstrated various therapeutic properties such as anti-inflammatory, antioxidant, and anti-cancer effects. However, its clinical application is limited by its poor bioavailability, which stems from its low solubility, rapid metabolism, and quick systemic elimination. Modifications in the chemical structure of curcumin have been employed to improve its pharmacokinetic properties. Incorporating various functional groups into the curcumin molecule can significantly impact its activity. Creating hybrid molecules by combining curcumin with other bioactive compounds can result in synergistic effects. The structural development of curcumin aims to enhance its therapeutic efficacy by improving its bioavailability, stability, and specific activity against various diseases. These new molecules could offer improved potency and target specific therapeutic areas more effectively. This review explores the serendipitous discoveries and rational design approaches that have contributed to curcumin's development as a potent therapeutic agent which can unlock a broader spectrum of therapeutic applications.

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.