Multi-collimator proton minibeam radiotherapy with joint dose and PVDR optimization

IF 3.2 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Medical physics Pub Date : 2024-11-28 DOI:10.1002/mp.17548

Weijie Zhang, Xue Hong, Wei Wu, Chao Wang, Daniel Johnson, Gregory N. Gan, Yuting Lin, Hao Gao

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引用次数: 0

Abstract

Background

The clinical translation of proton minibeam radiation therapy (pMBRT) presents significant challenges, particularly in developing an optimal treatment planning technique. A uniform target dose is crucial for maximizing anti-tumor efficacy and facilitating the clinical acceptance of pMBRT. However, achieving a high peak-to-valley dose ratio (PVDR) in organs-at-risk (OAR) is essential for sparing normal tissue. This balance becomes particularly difficult when OARs are located distal to the beam entrance or require patient-specific collimators.

Purpose

This work proposes a novel pMBRT treatment planning method that can achieve high PVDR at OAR and uniform dose at target simultaneously, via multi-collimator pMBRT (MC-pMBRT) treatment planning method with joint dose and PVDR optimization (JDPO).

Methods

MC-pMBRT utilizes a set of generic and premade multi-slit collimators with different center-to-center distances and does not need patient-specific collimators. The collimator selection per field is OAR-specific and tailored to maximize PVDR in OARs while preserving target dose uniformity. Then, the inverse optimization method JDPO is utilized to jointly optimize target dose uniformity, PVDR, and other dose-volume-histogram based dose objectives, which is solved by iterative convex relaxation optimization algorithm and alternating direction method of multipliers.

Results

The need and efficacy of MC-pMBRT is demonstrated by comparing the single-collimator (SC) approach with the multi-collimator (MC) approach. While SC degraded either PVDR for OAR or dose uniformity for the target, MC provided a good balance of PVDR and target dose uniformity. The proposed JDPO method is validated in comparison with the dose-only optimization (DO) method for MC-pMBRT, in reference to the conventional (CONV) proton RT (no pMBRT). Compared to CONV, MC-pMBRT (DO and JDPO) preserved target dose uniformity and plan quality, while providing unique PVDR in OAR. Compared to DO, JDPO further improved PVDR via PVDR optimization during treatment planning.

Conclusion

A novel pMBRT treatment planning method called MC-pMBRT is proposed that utilizes a set of generic and premade collimators with joint dose and PVDR optimization algorithm to optimize OAR-specific PVDR and target dose uniformity simultaneously.

查看原文本刊更多论文

采用联合剂量和 PVDR 优化的多准直器质子微型束放疗。

背景：质子微束放射治疗（pMBRT）的临床应用面临重大挑战，尤其是在开发最佳治疗计划技术方面。均匀的靶剂量对于最大限度地提高抗肿瘤疗效和促进 pMBRT 的临床应用至关重要。然而，在危险器官（OAR）中达到较高的峰谷剂量比（PVDR）对于保护正常组织至关重要。目的：这项研究提出了一种新的 pMBRT 治疗计划方法，通过多准直器 pMBRT（MC-pMBRT）治疗计划方法与联合剂量和 PVDR 优化（JDPO），可同时在 OAR 处实现高 PVDR 和靶区均匀剂量：方法：MC-pMBRT 利用一组通用的、预制的、具有不同中心到中心距离的多狭缝准直器，不需要患者专用准直器。每个射野的准直器选择是针对 OAR 的，目的是在保持靶剂量均匀性的同时，使 OAR 的 PVDR 最大化。然后，利用反向优化方法 JDPO 联合优化靶剂量均匀性、PVDR 和其他基于剂量-容积-柱状图的剂量目标，并通过迭代凸松弛优化算法和乘数交替方向法求解：结果：通过比较单准直器（SC）方法和多准直器（MC）方法，证明了 MC-pMBRT 的必要性和有效性。单准直器法降低了 OAR 的 PVDR 或靶的剂量均匀性，而多准直器法则很好地平衡了 PVDR 和靶的剂量均匀性。与传统（CONV）质子 RT（无 pMBRT）相比，提出的 JDPO 方法与 MC-pMBRT 的纯剂量优化（DO）方法进行了比较验证。与 CONV 相比，MC-pMBRT（DO 和 JDPO）保持了靶剂量均匀性和计划质量，同时在 OAR 中提供了独特的 PVDR。与DO相比，JDPO通过在治疗计划中优化PVDR，进一步提高了PVDR：结论：本文提出了一种名为 MC-pMBRT 的新型 pMBRT 治疗规划方法，该方法利用一组通用和预制准直器以及联合剂量和 PVDR 优化算法来同时优化 OAR 特定的 PVDR 和靶剂量均匀性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical physics 医学-核医学

CiteScore

6.80

自引率

15.80%

发文量

660

审稿时长

1.7 months

期刊介绍： Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.