Correlation between motor symptoms, cognitive function, and optical coherence tomography findings in Parkinson's disease.

IF 1.1 4区 医学 Q3 OPHTHALMOLOGY
Arquivos brasileiros de oftalmologia Pub Date : 2024-11-22 eCollection Date: 2024-01-01 DOI:10.5935/0004-2749.2024-0049
Leonardo Provetti Cunha, Pedro Nascimento Martins, Luiza Cunha Martins, Fernanda Mara do Nascimento Almada, Nádia Shigaeff, Daniel Oliveira de Araújo, Luiz Guilherme Marchesi Mello, Mário Luiz Ribeiro Monteiro, Peter J Snyder, Thiago Cardoso Vale
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引用次数: 0

Abstract

Purpose: This study aimed to evaluate the total macular thickness as well as the thickness of the inner and outer retinal layers in patients with Parkinson's disease. It also aimed to verify the correlation of these parameters with motor symptoms and cognitive function.

Methods: A total of 46 eyes of 23 patients with Parkinson's disease and 40 eyes of 20 healthy controls were included in the study. The patients' cognitive, functional, and nonmotor symptoms were evaluated using the Katz Index of Independence and Pfeffer's Activities of Daily Living, Mini-Mental State Examination, Frontal Assessment Battery, Schwab and England Staging Scales, and Movement Disorders Society Nonmotor Symptoms Scale. The macular thickness measurements obtained via total, inner, and outer optical coherence tomography were recorded. Furthermore, the correlation of the parameters of optical coherence tomography with cognitive, functional, and nonmotor symptoms was assessed.

Results: The scores of the Katz Index of Independence and Pfeffer's Activities of Daily Living as well as the Movement Disorders Society Nonmotor Symptoms Scale were significantly lower in patients with Parkinson's disease than in healthy controls. Moreover, the former had greater total macular thickness. The temporal and inferior outer sectors were significantly greater for the ganglion cell complex thickness in patients. A significant correlation was observed between the total macular thickness and the Movement Disorder Society-Unified Parkinson's Disease Rating Scale, Parte III (MDS-UPDRS-III) values. Contrarily, there was a negative correlation between the outer macular thickness and the MDS-UPDRS-III values. Meanwhile, the total macular thickness and ganglion cell complex thickness were significantly correlated with the scores of the Mini-Mental State Examination, Schwab and England Staging Scale, Frontal Assessment Battery, and Katz Index of Independence and Pfeffer's Activities of Daily Living. In addition, the Schwab and England scale was correlated with the outer macular thickness.

Conclusion: The total and inner macular thicknesses at the temporal and inferior outer sectors were greater in patients with Parkinson's disease than in the control group. These findings indicate that macular thickness may be greater in those with Parkinson's disease, particularly when associated with mild motor symptoms. In addition, the parameters of the total, inner, and outer optical coherence tomography were significantly associated with motor and nonmotor symptoms as well as cognitive function impairment.

帕金森病患者的运动症状、认知功能和光学相干断层扫描结果之间的相关性。
目的:本研究旨在评估帕金森病患者的黄斑总厚度以及视网膜内外层的厚度。研究还旨在验证这些参数与运动症状和认知功能的相关性:研究共纳入了 23 名帕金森病患者的 46 只眼睛和 20 名健康对照者的 40 只眼睛。使用卡茨独立指数和普费弗日常生活活动指数、迷你精神状态检查、额叶评估电池、施瓦布和英格兰分期量表以及运动障碍协会非运动症状量表对患者的认知、功能和非运动症状进行了评估。此外,还记录了通过总、内、外光学相干断层扫描获得的黄斑厚度测量结果。此外,还评估了光学相干断层扫描参数与认知、功能和非运动症状的相关性:结果:帕金森病患者的卡茨独立指数和普费弗日常生活活动指数以及运动障碍协会非运动症状量表的得分明显低于健康对照组。此外,前者的黄斑总厚度更大。患者颞部和下外侧的神经节细胞复合体厚度明显更大。黄斑总厚度与运动障碍协会-统一帕金森病评分量表第三部分(MDS-UPDRS-III)的数值之间存在明显的相关性。相反,黄斑外侧厚度与 MDS-UPDRS-III 值呈负相关。同时,黄斑总厚度和神经节细胞复合体厚度与迷你精神状态检查、施瓦布和英格兰分期量表、额叶评估电池、卡茨独立性指数和普费弗日常生活活动指数的评分显著相关。此外,施瓦布和英格兰分期量表与黄斑外侧厚度也有相关性:结论:帕金森病患者颞部和下外侧的黄斑总厚度和内侧厚度均大于对照组。这些发现表明,帕金森病患者的黄斑厚度可能更大,尤其是伴有轻微运动症状时。此外,总体、内部和外部光学相干断层扫描的参数与运动和非运动症状以及认知功能障碍有显著相关性。
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
200
审稿时长
6-12 weeks
期刊介绍: The ABO-ARQUIVOS BRASILEIROS DE OFTALMOLOGIA (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - electronic version), the official bimonthly publication of the Brazilian Council of Ophthalmology (CBO), aims to disseminate scientific studies in Ophthalmology, Visual Science and Health public, by promoting research, improvement and updating of professionals related to the field.
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