Pan-cancer analysis identifies the oncogenic role of CCNE1 in human cancers.

IF 3.9 3区医学 Q2 CELL BIOLOGY

Aging-Us Pub Date : 2024-11-25 DOI:10.18632/aging.206163

Yujie Ouyang, Ziyi Wu, Dilihumaer Aili, Chunhua Yang, Hui Zhang, Tong Wu

{"title":"Pan-cancer analysis identifies the oncogenic role of CCNE1 in human cancers.","authors":"Yujie Ouyang, Ziyi Wu, Dilihumaer Aili, Chunhua Yang, Hui Zhang, Tong Wu","doi":"10.18632/aging.206163","DOIUrl":null,"url":null,"abstract":"Objective: To investigate expression, prognosis, immune cell infiltration of Cyclin E1 (CCNE1) in cancer.Methods: We used TIMER and GEPIA datasets to analyze the differential expression of CCNE1 in multiple tumors. GEPIA and Kaplan-Meier plotter databases were utilized to observe the prognostic significance of CCNE1 in cancer. TIMER and cBioPortal databases were adopted for the analysis regarding immune infiltration and mutation respectively.Results: The results showed that CCNE1 was highly expressed in multiple cancers including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, KICH, KIRC, KIRP, LIHC, LUAD, LUSC, READ, STAD, THCA, UCEC (P < 0.001) and CESC (P < 0.01). High CCNE1 expression was associated with a poor overall survival prognosis in several cancers, including ACC, BRCA, KIRC, KIRP, LGG, LIHC, LUAD and MESO. Additionally, CCNE1 expression was correlated with the cancer-associated immune infiltration level in BRCA, COAD, LUSC, STAD and THYM.Conclusions: CCNE1 is expected to be a potential biomarker for tumor prognosis and immune infiltration in various cancers.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"13392-13408"},"PeriodicalIF":3.9000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719100/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging-Us","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18632/aging.206163","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To investigate expression, prognosis, immune cell infiltration of Cyclin E1 (CCNE1) in cancer.

Methods: We used TIMER and GEPIA datasets to analyze the differential expression of CCNE1 in multiple tumors. GEPIA and Kaplan-Meier plotter databases were utilized to observe the prognostic significance of CCNE1 in cancer. TIMER and cBioPortal databases were adopted for the analysis regarding immune infiltration and mutation respectively.

Results: The results showed that CCNE1 was highly expressed in multiple cancers including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, KICH, KIRC, KIRP, LIHC, LUAD, LUSC, READ, STAD, THCA, UCEC (P < 0.001) and CESC (P < 0.01). High CCNE1 expression was associated with a poor overall survival prognosis in several cancers, including ACC, BRCA, KIRC, KIRP, LGG, LIHC, LUAD and MESO. Additionally, CCNE1 expression was correlated with the cancer-associated immune infiltration level in BRCA, COAD, LUSC, STAD and THYM.

Conclusions: CCNE1 is expected to be a potential biomarker for tumor prognosis and immune infiltration in various cancers.

查看原文本刊更多论文

泛癌分析确定了 CCNE1 在人类癌症中的致癌作用。

目的研究 Cyclin E1（CCNE1）在癌症中的表达、预后和免疫细胞浸润：我们使用 TIMER 和 GEPIA 数据集分析了 CCNE1 在多种肿瘤中的差异表达。利用 GEPIA 和 Kaplan-Meier plotter 数据库观察 CCNE1 在癌症中的预后意义。TIMER和cBioPortal数据库分别用于分析免疫浸润和基因突变：结果显示，CCNE1在多种癌症中高表达，包括BLCA、BRCA、CHOL、COAD、ESCA、HNSC、KICH、KIRC、KIRP、LIHC、LUAD、LUSC、READ、STAD、THCA、UCEC（P < 0.001）和CESC（P < 0.01）。在多种癌症中，CCNE1的高表达与总生存预后不良有关，包括ACC、BRCA、KIRC、KIRP、LGG、LIHC、LUAD和MESO。此外，在BRCA、COAD、LUSC、STAD和THYM中，CCNE1的表达与癌症相关免疫浸润水平相关：结论：CCNE1有望成为各种癌症中肿瘤预后和免疫浸润的潜在生物标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊