Advances in Loading Techniques and Quality by Design for Fused Deposition Modeling in Pharmaceutical Production: A Systematic Review.

IF 4.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Pharmaceuticals Pub Date : 2024-11-07 DOI:10.3390/ph17111496

Yusra Ahmed, Azza A K Mahmoud, Krisztina Ludasi, Tamás Sovány

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引用次数: 0

Abstract

Background/objectives: Three-dimensional printing technology has emerging interest in pharmaceutical manufacturing, offering new opportunities for personalized medicine and customized drug delivery systems. Fused deposition modeling (FDM) is highly regarded in the pharmaceutical industry because of its cost effectiveness, easy operation, and versatility in creating pharmaceutical dosage forms. This review investigates different methods of incorporating active pharmaceutical ingredients (APIs) into filament matrices for use in fused deposition modeling (FDM) 3D printing.

Methods: Two electronic databases, the Web of Science and PubMed, were utilized to survey the literature. The selected keywords for this review were as follows: fused filament fabrication OR fused deposition modeling OR FDM OR FFF AND 3D printing AND loading techniques OR impregnation techniques AND solid dosage form.

Results: This paper evaluates various loading techniques such as soaking, supercritical impregnation, microwave impregnation, and hot-melt extrusion, focusing on their effectiveness and capacity for drug incorporation. Additionally, this review includes a thorough risk assessment of the extrusion process using Ishikawa and SWOT analyses.

Conclusions: Overall, this review provides comprehensive insights into the latest advancements in 3D printing for pharmaceutical applications and identifies key areas for future research and development.

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制药生产中熔融沉积建模的装载技术和设计质量的进步：系统回顾。

背景/目标：三维打印技术为个性化医疗和定制给药系统提供了新的机遇，在医药制造领域备受关注。熔融沉积建模（FDM）因其成本效益高、操作简便以及在创建药物剂型方面的多功能性而在制药行业备受推崇。本综述研究了在熔融沉积建模（FDM）三维打印中将活性药物成分（API）融入长丝基质的不同方法：方法：利用 Web of Science 和 PubMed 这两个电子数据库调查文献。本综述选取的关键词如下：熔融长丝制造或熔融沉积建模或 FDM 或 FFF、3D 打印、加载技术或浸渍技术、固体制剂：本文评估了浸泡、超临界浸渍、微波浸渍和热熔挤出等各种装载技术，重点关注其药物掺入的效果和能力。此外，本综述还利用石川分析和 SWOT 分析对挤压工艺进行了全面的风险评估：总之，本综述全面介绍了三维打印在制药应用方面的最新进展，并确定了未来研发的关键领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceuticals Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.10

自引率

4.30%

发文量

1332

审稿时长

6 weeks

期刊介绍： Pharmaceuticals (ISSN 1424-8247) is an international scientific journal of medicinal chemistry and related drug sciences.Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details. Short communications are also accepted; therefore, there is no restriction on the maximum length of the papers.