Effect of low-dose dexmedetomidine to prolong spinal anesthesia in elderly patients: a prospective randomized controlled study.

IF 2.3 3区 医学 Q2 ANESTHESIOLOGY
Lisa Sangkum, Sivaporn Termpornlert, Choosak Tunprasit, Chatchayapa Rathanasutthajohn, Rojnarin Komonhirun, Sasima Dusitkasem
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Abstract

Background: Spinal anesthesia for transurethral resection of the prostate (TURP) has a short duration, which poses challenges for postoperative pain management. The present study aimed to investigate the effects of intravenous (IV) dexmedetomidine at a dosage of 0.4 µg/kg in prolonging the duration of spinal anesthesia and minimizing postoperative pain in elderly patients undergoing TURP.

Methods: This prospective randomized controlled trial enrolled 38 patients aged 60-80 years who underwent elective TURP with spinal anesthesia. The patients were randomly assigned to two treatment groups: Group D received IV 0.4 µg/kg dexmedetomidine, whereas Group C received IV normal saline after spinal anesthesia administration. The primary outcome was the time to 2-dermatome regression.

Results: The 2-dermatome regression time was longer in Group D than in Group C (104.44 ± 16.97 min vs. 80.63 ± 15.59 min, p < 0.05). The peak sensory block levels were significantly higher in Group D [T7 (T6-T8)] than in Group C [T10 (T7-T10)] (p = 0.017). The incidence of hypotension and bradycardia and postoperative pain at 0, 6, 12, and 24 h were not different between two groups.

Conclusion: Intravenous dexmedetomidine at a dosage of 0.4 µg/kg significantly prolongs the duration of spinal sensory blockade. Although postoperative analgesia was not different, it provided hemodynamic stability without increasing the side effects.

小剂量右美托咪定延长老年患者脊髓麻醉时间的效果:一项前瞻性随机对照研究。
背景:经尿道前列腺切除术(TURP)的脊髓麻醉持续时间较短,这给术后疼痛管理带来了挑战。本研究旨在探讨剂量为 0.4 µg/kg 的静脉注射右美托咪定对延长经尿道前列腺电切术(TURP)老年患者脊髓麻醉时间和减少术后疼痛的影响:这项前瞻性随机对照试验共纳入了 38 名年龄在 60-80 岁之间、在脊髓麻醉下接受择期 TURP 的患者。患者被随机分配到两个治疗组:D组接受0.4 µg/kg右美托咪定静脉注射,而C组在脊髓麻醉后接受生理盐水静脉注射。主要结果是2个皮损消退的时间:结果:D 组的 2 个皮质体消退时间长于 C 组(104.44 ± 16.97 分钟 vs. 80.63 ± 15.59 分钟,P以 0.4 µg/kg 的剂量静脉注射右美托咪定可显著延长脊髓感觉阻滞的持续时间。虽然术后镇痛效果并无差异,但它能在不增加副作用的情况下稳定血流动力学。
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来源期刊
BMC Anesthesiology
BMC Anesthesiology ANESTHESIOLOGY-
CiteScore
3.50
自引率
4.50%
发文量
349
审稿时长
>12 weeks
期刊介绍: BMC Anesthesiology is an open access, peer-reviewed journal that considers articles on all aspects of anesthesiology, critical care, perioperative care and pain management, including clinical and experimental research into anesthetic mechanisms, administration and efficacy, technology and monitoring, and associated economic issues.
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